INT221167

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 0.69
Pain Relevance 11.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Flna) plasma membrane (Flna) nucleus (Flna)
transcription factor binding (Flna) biological_process (Flna) cytoplasm (Flna)
Anatomy Link Frequency
SK-N-MC 1
brain 1
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 1231 99.92 Very High Very High Very High
narcan 1281 99.76 Very High Very High Very High
addiction 191 99.54 Very High Very High Very High
Morphine 578 99.20 Very High Very High Very High
Opioid 626 97.92 Very High Very High Very High
tolerance 239 97.64 Very High Very High Very High
analgesia 109 79.36 Quite High
antagonist 175 78.16 Quite High
opiate 32 71.76 Quite High
Analgesic 59 60.68 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 10 99.44 Very High Very High Very High
Skin Cancer 30 95.68 Very High Very High Very High
Vibrio Infection 10 76.72 Quite High
Bordatella Infection 3 44.08 Quite Low
Drug Dependence 16 5.00 Very Low Very Low Very Low
Decapitation 13 5.00 Very Low Very Low Very Low
Injury 13 5.00 Very Low Very Low Very Low
Opiate Addiction 12 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Hyperalgesia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We first confirmed FLNA expression in A7 cells and absence in M2 cells by Western blotting using a specific anti-FLNA antibody (Table 1).
Gene_expression (expression) of FLNA
1) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.18 Pain Relevance 0.94
Membranes prepared from the parent M2 cells (200 µg) that do not express FLNA served as a negative control for [3H]NLX binding, and A7 cell membranes (200 µg) incubated with 2 nM [3H]DAMGO illustrated the lack of MOR in both cell lines.
Neg (not) Gene_expression (express) of FLNA associated with mu opioid receptor and narcan
2) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.08 Pain Relevance 0.47
FLNA was also detected in the human neuroblastoma SK-N-MC cell line and in rat cortical membranes (Table 1).
Gene_expression (detected) of FLNA in SK-N-MC associated with neuroblastoma
3) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.19 Pain Relevance 0.97
The dependence of [3H]NLX binding on FLNA expression in cell lines, the absence of MOR in these cell lines, and the displacement by naltrexone but not morphine clarified FLNA as a novel target for NLX and naltrexone.
Gene_expression (expression) of FLNA associated with addiction, mu opioid receptor, narcan and morphine
4) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.26
The presence of FLNA in MOR signalplex in native brain tissues demonstrated here by co-immunoprecipitation agrees with previous data using yeast-two hybrid and co-transfection methods [15].
Gene_expression (presence) of FLNA in brain associated with mu opioid receptor
5) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.38
Determination of binding site using FLNA peptides
Gene_expression (using) of FLNA
6) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 0.38
The detection of FLNA in immunoprecipitates containing Go-coupled MOR and not Gs-coupled MOR appears counterintuitive since NLX prevents MOR–Gs coupling via a tight binding to FLNA.
Gene_expression (detection) of FLNA associated with narcan and mu opioid receptor
7) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.33
MOR and FLNA might be forced into an altered conformation or interaction during opioid tolerance by proteins involved in MOR recycling and internalization such as ?
Gene_expression (forced) of FLNA associated with tolerance, mu opioid receptor and opioid
8) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.08 Pain Relevance 1.30
A competition (displacement) curve was generated for the inhibition of [3H]NLX binding by naltrexone to membranes prepared as described above from FLNA-expressing A7 cells.
Gene_expression (expressing) of FLNA associated with narcan
9) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 0.36
NLX binding in FLNA-expressing cells and affinity measurement
Gene_expression (expressing) of FLNA associated with narcan
10) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0.16 Pain Relevance 0.97
Assessment of VAKGL peptide binding to MOR and FLNA proteins
Gene_expression (proteins) of FLNA associated with mu opioid receptor
11) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 0.40
VAKGL binding to MOR or FLNA proteins
Gene_expression (proteins) of FLNA associated with mu opioid receptor
12) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.10
Acute morphine-induced G protein coupling switch blocked by 100 pM NLX/NTX or 10 µM FLNA pentapeptide
Gene_expression (pentapeptide) of FLNA associated with narcan and morphine
13) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 0.95

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