INT221197

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.99
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gja3) plasma membrane (Gja3)
Anatomy Link Frequency
myocytes 1
hearts 1
Gja3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 76 97.20 Very High Very High Very High
ischemia 7 97.16 Very High Very High Very High
Action potential 12 87.52 High High
isoflurane 1 79.20 Quite High
anesthesia 1 78.32 Quite High
potassium channel 154 58.44 Quite High
action potential duration 28 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 138 98.64 Very High Very High Very High
Reperfusion Injury 60 97.40 Very High Very High Very High
Injury 12 92.16 High High
Parkinson's Disease 232 57.60 Quite High
Sprains And Strains 1 19.44 Low Low
Stress 38 5.00 Very Low Very Low Very Low
Apoptosis 32 5.00 Very Low Very Low Very Low
Targeted Disruption 21 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Thrombosis Related Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ventricular myocytes were isolated from Cx43+/?
Phosphorylation (isolated) of Cx43 in myocytes
1) Confidence 0.71 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.12
Studies in both pig and rat hearts demonstrated that the dephosphorylation of Cx43 and electrical uncoupling during ischaemia were prevented by IP in a PKC-dependent manner and that IP increased the co-localization of several protein kinases with Cx43 during ischemia [262,263].
Phosphorylation (dephosphorylation) of Cx43 in hearts associated with kinase c, ischemia and cv unclassified under development
2) Confidence 0.22 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.61 Pain Relevance 0.21
Cx43 is normally partially phosphorylated with low conductance, but progressive dephosphorylation occurs during ischemia causing increased conductance.
Phosphorylation (phosphorylated) of Cx43 associated with ischemia
3) Confidence 0.22 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.38 Pain Relevance 0.23

General Comments

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