INT221386

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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 3.5254
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 3.53
 
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 1.80432
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 0.90
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cytokine]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cytokine]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 60
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 60
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[antagonist]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[antagonist]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 24
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 24
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.4
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.40
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Lasting pain]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Lasting pain]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
|-
 
|-
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[anti-cytokine treatment]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[anti-cytokine treatment]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
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| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Fungal Infection]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Fungal Infection]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 90.4
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 90.40
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
|-
 
|-
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Critical Illness]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Critical Illness]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 84
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 84.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855078 PMC2855078]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2855078 PMC2855078]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.35
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.04
 
|}
 
|}
 
|-
 
|-
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2695202 PMC2695202]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2695202 PMC2695202]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.44
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.26
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| As expected, it should be pointed that <span style="background-color:#FFFF00">LPS</span>-<span style="background-color:#B0E0E6">induced</span> <span style="background-color:#FFFF00">IL-8</span> <span style="background-color:#B0E0E6">levels</span> varied among COPD patients, suggesting that <span style="background-color:#FFDEAD">epithelial cell</span> responsiveness to LPS cannot alone explain the complex inflammatory process of COPD.
+
| As expected, it should be pointed that <span style="background-color:#FFFF00">LPS</span>-<span style="background-color:#B0E0E6">induced</span> <span style="background-color:#FFFF00">IL-8</span> <span style="background-color:#B0E0E6">levels</span> varied among <span style="background-color:#FFA07A">COPD</span> patients, suggesting that <span style="background-color:#FFDEAD">epithelial cell</span> responsiveness to LPS cannot alone explain the complex <span style="background-color:#FFA07A">inflammatory</span> process of <span style="background-color:#FFA07A">COPD</span>.
  
 
|-
 
|-
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''LPS'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">induced</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">levels</span>) of <span style="color:#800000">'''IL-8'''</span> in <span style="color:#808000">epithelial cell</span>
+
| <span style="color:#800000">'''LPS'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">induced</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">levels</span>) of <span style="color:#800000">'''IL-8'''</span> in <span style="color:#808000">epithelial cell</span> associated with <span style="color:#FF0000">'''pulmonary disease'''</span> and <span style="color:#FF0000">'''inflammation'''</span>
 
|-
 
|-
 
|}
 
|}
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2214730 PMC2214730]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2214730 PMC2214730]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.79
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.20
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Indeed, it was found that a constitutively active mutant of human <span style="background-color:#FFFF00">TLR4</span>, transfected into a monocytic cell line, could <span style="background-color:#B0E0E6">induce</span> the activation of NF-kappaB and the <span style="background-color:#B0E0E6">expression</span> of the proinflammatory cytokines IL-1, IL-6, and <span style="background-color:#FFFF00">IL-8</span> as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve <span style="background-color:#FFDEAD">T lymphocytes</span> [66].  
+
| Indeed, it was found that a constitutively active mutant of human <span style="background-color:#FFFF00">TLR4</span>, transfected into a monocytic cell line, could <span style="background-color:#B0E0E6">induce</span> the activation of NF-kappaB and the <span style="background-color:#B0E0E6">expression</span> of the proinflammatory <span style="background-color:#FFA07A">cytokines</span> IL-1, IL-6, and <span style="background-color:#FFFF00">IL-8</span> as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve <span style="background-color:#FFDEAD">T lymphocytes</span> [66].  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR4'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">induce</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">expression</span>) of <span style="color:#800000">'''IL-8'''</span> in <span style="color:#808000">T lymphocytes</span>
+
| <span style="color:#800000">'''TLR4'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">induce</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">expression</span>) of <span style="color:#800000">'''IL-8'''</span> in <span style="color:#808000">T lymphocytes</span> associated with <span style="color:#FF0000">'''cytokine'''</span>
 
|-
 
|-
 
|}
 
|}
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| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2817369 PMC2817369]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2817369 PMC2817369]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.27
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.11
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Indeed, it was found that a constitutively active mutant of human <span style="background-color:#FFFF00">TLR4</span>, transfected into a monocytic cell line, could <span style="background-color:#B0E0E6">induce</span> the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and <span style="background-color:#FFFF00">IL-8</span> as well as the <span style="background-color:#B0E0E6">expression</span> of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve <span style="background-color:#FFDEAD">T lymphocytes</span> [66].  
+
| Indeed, it was found that a constitutively active mutant of human <span style="background-color:#FFFF00">TLR4</span>, transfected into a monocytic cell line, could <span style="background-color:#B0E0E6">induce</span> the activation of NF-kappaB and the expression of the proinflammatory <span style="background-color:#FFA07A">cytokines</span> IL-1, IL-6, and <span style="background-color:#FFFF00">IL-8</span> as well as the <span style="background-color:#B0E0E6">expression</span> of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve <span style="background-color:#FFDEAD">T lymphocytes</span> [66].  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''TLR4'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">induce</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">expression</span>) of <span style="color:#800000">'''IL-8'''</span> in <span style="color:#808000">T lymphocytes</span>
+
| <span style="color:#800000">'''TLR4'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">induce</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">expression</span>) of <span style="color:#800000">'''IL-8'''</span> in <span style="color:#808000">T lymphocytes</span> associated with <span style="color:#FF0000">'''cytokine'''</span>
 
|-
 
|-
 
|}
 
|}
Line 415: Line 415:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2817369 PMC2817369]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2817369 PMC2817369]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.32
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.11
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Conversely, the P2RY6 receptor antagonists, anthraquinone-sulfonic acid derivative reactive blue 2 and suramin, inhibited <span style="background-color:#FFFF00">LPS</span>-<span style="background-color:#B0E0E6">induced</span> <span style="background-color:#FFFF00">IL-8</span> <span style="background-color:#B0E0E6">production</span> by <span style="background-color:#FFDEAD">THP-1</span> cells [24].  
+
| Conversely, the P2RY6 receptor <span style="background-color:#FFA07A">antagonists</span>, anthraquinone-sulfonic acid derivative reactive blue 2 and suramin, inhibited <span style="background-color:#FFFF00">LPS</span>-<span style="background-color:#B0E0E6">induced</span> <span style="background-color:#FFFF00">IL-8</span> <span style="background-color:#B0E0E6">production</span> by <span style="background-color:#FFDEAD">THP-1</span> cells [24].  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''LPS'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">induced</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">production</span>) of <span style="color:#800000">'''IL-8'''</span> in <span style="color:#808000">THP-1</span>
+
| <span style="color:#800000">'''LPS'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">induced</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">production</span>) of <span style="color:#800000">'''IL-8'''</span> in <span style="color:#808000">THP-1</span> associated with <span style="color:#FF0000">'''antagonist'''</span>
 
|-
 
|-
 
|}
 
|}
Line 446: Line 446:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2394514 PMC2394514]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC2394514 PMC2394514]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.35
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.19
 
|}
 
|}
 
|-
 
|-

Revision as of 12:28, 14 September 2012

Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.53
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, IL8) intracellular (Tlr4, IL8) extracellular space (IL8)
extracellular region (IL8) plasma membrane (Tlr4) cytoplasm (Tlr4)
Anatomy Mention Frequency
T lymphocytes 4
THP-1 2
epithelial cell 2
Tlr4 (Mus musculus)
IL8 (Homo sapiens)
Pain Term Frequency Confidence Heat
cytokine 60 100.00 Very High Very High Very High
antagonist 24 98.40 Very High Very High Very High
Inflammation 163 95.36 Very High Very High Very High
agonist 14 91.16 High High
Inflammatory mediators 10 88.96 High High
chemokine 29 87.36 High High
Inflammatory response 30 73.52 Quite High
Inflammatory stimuli 7 54.92 Quite High
Lasting pain 1 5.00 Very Low Very Low Very Low
anti-cytokine treatment 1 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Pulmonary Disease 251 99.44 Very High Very High Very High
Nicotine Addiction 69 98.08 Very High Very High Very High
INFLAMMATION 206 95.36 Very High Very High Very High
Fungal Infection 3 90.40 High High
Critical Illness 2 84.00 Quite High
Sepsis 41 81.68 Quite High
Bacterial Infection 3 66.56 Quite High
Sprains And Strains 9 63.56 Quite High
Hypoxia 2 57.04 Quite High
Injury 12 54.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonetheless, vitamin D3 pretreatment resulted in decreased LPS-induced IL-6 and IL-8 production and blocked NF?
LPS Positive_regulation (induced) of Gene_expression (production) of IL-8
1) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.35 Pain Relevance 0.04
B and IKK-2 impaired the CXCL8 expression this points to a TLR4 and NF-?
TLR4 Positive_regulation (points) of Gene_expression (expression) of CXCL8
2) Confidence 0.07 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.44 Pain Relevance 0.26
As expected, it should be pointed that LPS-induced IL-8 levels varied among COPD patients, suggesting that epithelial cell responsiveness to LPS cannot alone explain the complex inflammatory process of COPD.
LPS Positive_regulation (induced) of Gene_expression (levels) of IL-8 in epithelial cell associated with pulmonary disease and inflammation
3) Confidence 0.05 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 1.79 Pain Relevance 0.20
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
TLR4 Positive_regulation (induce) of Gene_expression (expression) of IL-8 in T lymphocytes associated with cytokine
4) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.27 Pain Relevance 0.11
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
TLR4 Positive_regulation (induce) of Gene_expression (expression) of IL-8 in T lymphocytes associated with cytokine
5) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.32 Pain Relevance 0.11
Conversely, the P2RY6 receptor antagonists, anthraquinone-sulfonic acid derivative reactive blue 2 and suramin, inhibited LPS-induced IL-8 production by THP-1 cells [24].
LPS Positive_regulation (induced) of Gene_expression (production) of IL-8 in THP-1 associated with antagonist
6) Confidence 0.00 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.35 Pain Relevance 0.19

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