INT221386

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Context Info
Confidence 0.2959526900
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in NULL
Documents 6
Total Number 6

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, IL8) intracellular (Tlr4, IL8) extracellular space (IL8)
extracellular region (IL8) plasma membrane (Tlr4) cytoplasm (Tlr4)
Anatomy Mention Frequency
T lymphocytes 4
THP-1 2
epithelial cell 2
Tlr4 (Mus musculus)
IL8 (Homo sapiens)
Pain Term Frequency Confidence Heat
Inflammation 163 35.52 Quite Low
Lasting pain 1 5 Very Low Very Low Very Low
anti-cytokine treatment 1 5 Very Low Very Low Very Low
Central nervous system 6 5 Very Low Very Low Very Low
alcohol 2 5 Very Low Very Low Very Low
Bioavailability 11 5 Very Low Very Low Very Low
Inflammatory mediators 10 5 Very Low Very Low Very Low
Infliximab 4 5 Very Low Very Low Very Low
antagonist 24 5 Very Low Very Low Very Low
cytokine 60 5 Very Low Very Low Very Low
|
Disease Term Frequency Confidence Heat
Critical Illness 2 84 Quite High
Bacterial Infection 3 66.56 Quite High
Duodenal Ulcer 1 51.2 Quite High
Acid Reflux 1 49.12 Quite Low
INFLAMMATION 206 44.24 Quite Low
Shock 8 40.24 Quite Low
Mucositis 1 36.16 Quite Low
General Immunology 2 22.64 Low Low
Hyperoxia 1 5 Very Low Very Low Very Low
Fibrosis 1 5 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
Nonetheless, vitamin D3 pretreatment resulted in decreased LPS-induced IL-6 and IL-8 production and blocked NF?
LPS Positive_regulation (induced) of Gene_expression (production) of IL-8
1) Confidence 0.144078894800598 Published 2010 Journal N/A Section N/A Doc Link PMC2855078
B and IKK-2 impaired the CXCL8 expression this points to a TLR4 and NF-?
TLR4 Positive_regulation (points) of Gene_expression (expression) of CXCL8
2) Confidence 0.0664591614712042 Published 2007 Journal N/A Section N/A Doc Link PMC2695202
As expected, it should be pointed that LPS-induced IL-8 levels varied among COPD patients, suggesting that epithelial cell responsiveness to LPS cannot alone explain the complex inflammatory process of COPD.
LPS Positive_regulation (induced) of Gene_expression (levels) of IL-8 in epithelial cell
3) Confidence 0.0515229386507135 Published 2007 Journal N/A Section N/A Doc Link PMC2214730
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
TLR4 Positive_regulation (induce) of Gene_expression (expression) of IL-8 in T lymphocytes
4) Confidence 0.0149300598755011 Published 2010 Journal N/A Section N/A Doc Link PMC2817369
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
TLR4 Positive_regulation (induce) of Gene_expression (expression) of IL-8 in T lymphocytes
5) Confidence 0.0149300598755011 Published 2010 Journal N/A Section N/A Doc Link PMC2817369
Conversely, the P2RY6 receptor antagonists, anthraquinone-sulfonic acid derivative reactive blue 2 and suramin, inhibited LPS-induced IL-8 production by THP-1 cells [24].
LPS Positive_regulation (induced) of Gene_expression (production) of IL-8 in THP-1
6) Confidence 0.00403160642383578 Published 2008 Journal N/A Section N/A Doc Link PMC2394514

General Comments

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