INT221387

Context Info Confidence 0.05 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.98 Pain Relevance 0

signal transduction (Tlr4, IL8) intracellular (Tlr4, IL8) extracellular space (IL8) extracellular region (IL8) plasma membrane (Tlr4) cytoplasm (Tlr4)

Tlr4 (Mus musculus) IL8 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 44 50.00 Inflammatory mediators 14 5.00 Inflammatory response 14 5.00 cytokine 4 5.00 lidocaine 2 5.00 corticosteroid 2 5.00 anesthesia 2 5.00 Pyramidal cell 2 5.00 Inflammatory stimuli 2 5.00

Disease Link Frequency Relevance Heat Pulmonary Disease 214 99.24 Nicotine Addiction 40 97.72 INFLAMMATION 72 50.00 Disease 6 5.00 Injury 4 5.00 Lower Respiratory Tract Infection 4 5.00 Hyperplasia 2 5.00 Bacterial Infection 2 5.00 Pseudomonas Infection 2 5.00 Rhinitis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

LPS-induced IL-8 release by BES correlates with clinical/functional parameters of patients

LPS Positive_regulation (induced) of Localization (release) of IL-8

1) Confidence 0.05 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 1.67 Pain Relevance 0

In univariate analysis including all COPD and non-COPD smokers, basal levels of IL-8 release did not correlate with any clinical and functional parameters of the patients, and LPS-induced IL-8 release was not correlated with age, sex, weight, height and BMI (data not shown).

LPS Positive_regulation (induced) of Localization (release) of IL-8 associated with nicotine addiction and pulmonary disease

2) Confidence 0.05 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 1.30 Pain Relevance 0

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