INT221531

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.51
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Plxna1) intracellular (Plxna1)
Anatomy Link Frequency
sensory neurons 2
upper 2
neurons 1
Plxna1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 148 98.80 Very High Very High Very High
Nerve growth factor 99 90.84 High High
nociceptor 4 89.24 High High
c fibre 6 88.08 High High
chemokine 12 87.04 High High
Antihistamine 4 79.60 Quite High
Inflammation 27 78.48 Quite High
substance P 16 57.96 Quite High
antagonist 3 51.40 Quite High
cytokine 35 46.88 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 152 98.80 Very High Very High Very High
Disease 10 94.48 High High
Pruritus 48 92.80 High High
Hypersensitivity 8 92.20 High High
Skin Diseases 6 92.16 High High
Eczema 216 90.40 High High
INFLAMMATION 25 78.48 Quite High
Dengue 25 72.56 Quite High
Fever 5 68.08 Quite High
Infection 26 56.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
induces the expression of major histocompatibility complex class I molecules, enhancing antigen presentation and thereby triggering the acquired immune response.
Gene_expression (expression) of plex
1) Confidence 0.75 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC3013083 Disease Relevance 0.28 Pain Relevance 0.08
Semaphorin 3A (Sema3A), an axon guidance molecule, is a potent inhibitor of neurite outgrowth of sensory neurons by exerting the plexin-A1-4 and neuropilin-1 (NRP-1) of its receptors.32,33 Fig. 10 shows semaphorin family and its receptors.
Gene_expression (shows) of plexin-A1-4 in sensory neurons
2) Confidence 0.13 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 1.86 Pain Relevance 0.43
Semaphorin 3A (Sema3A), an axon guidance molecule, is a potent inhibitor of neurite outgrowth of sensory neurons by exerting the plexin-A1-4 and neuropilin-1 (NRP-1) of its receptors.32,33 Fig. 10 shows semaphorin family and its receptors.
Gene_expression (exerting) of plexin-A1-4 in sensory neurons
3) Confidence 0.13 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 1.82 Pain Relevance 0.43
In these in vitro assays, Fps was less active than Fer, but we could still see that Fps autophosphorylation activity was compromised by co-expression with PlexinA1.
Gene_expression (expression) of PlexinA1
4) Confidence 0.02 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.11 Pain Relevance 0.06
However, co-expression of PlexinA1 correlated with reduced autophosphorylation of both Fps and Fer (Fig. 4A, upper).
Gene_expression (expression) of PlexinA1 in upper
5) Confidence 0.02 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.13 Pain Relevance 0.07
However, co-expression of PlexinA1 correlated with reduced autophosphorylation of both Fps and Fer (Fig. 4A, upper).
Gene_expression (-) of PlexinA1 in upper
6) Confidence 0.02 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.13 Pain Relevance 0.07
It would be interesting to test Sema3A responsiveness in Fps- and/or Fer-deficient DRG-derived proprioceptive neurons selected with NT3, which do express PlexinA1 [19].
Gene_expression (express) of PlexinA1 in neurons associated with dorsal root ganglion
7) Confidence 0.02 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.18 Pain Relevance 0.18

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