INT221623

Context Info Confidence 0.14 First Reported 2007 Last Reported 2007 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.20 Pain Relevance 0.03

plasma membrane (Fyn, Fes) kinase activity (Fyn, Fes) endosome (Fyn) mitochondrion (Fyn) Golgi apparatus (Fes) cytoplasm (Fes)

Anatomy Link Frequency mast cells 1 Fyn (Mus musculus) Fes (Mus musculus)

Pain Link Frequency Relevance Heat dorsal root ganglion 37 51.28 withdrawal 1 5.00 Root ganglion neuron 1 5.00 nociceptor 1 5.00

Disease Link Frequency Relevance Heat Shock 22 94.20 Ganglion Cysts 38 51.28 Adhesions 1 46.08 Apoptosis 3 5.00 Targeted Disruption 3 5.00 Sprains And Strains 2 5.00 Death 1 5.00 Wallerian Degeneration 1 5.00 Urological Neuroanatomy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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There is also evidence that Fyn might regulate Fps, and possibly Fer, as Fyn has been shown to phosphorylate a kinase-defective mutant form of Fps in Sf-9 cells [45], Fer and Fyn cooperate in actin depolymerization-induced cortactin phosphorylation [26], and the Fyn-related Lyn kinase regulates Fer phosphorylation in mast cells downstream of the IgE receptor engagement [46].

Fyn Spec (might) Regulation (regulate) of Fps in mast cells

1) Confidence 0.14 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.20 Pain Relevance 0.03

General Comments

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