INT2219

Context Info Confidence 0.45 First Reported 1979 Last Reported 1996 Negated 5 Speculated 1 Reported most in Abstract Documents 11 Total Number 12 Disease Relevance 0.79 Pain Relevance 6.73

Anatomy Link Frequency plasma 6 blood 2 pons 2 cortex 2 LH (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 38 100.00 methadone 18 100.00 Morphine 14 100.00 Intracerebroventricular 9 99.84 Spinal cord 1 98.64 opiate 6 97.28 Raphe magnus 2 96.64 Dopamine 1 95.88 lidocaine 2 95.64 Central grey 2 95.48

Disease Link Frequency Relevance Heat Aids-related Complex 4 100.00 Stress 3 100.00 Urological Neuroanatomy 2 95.48 Body Weight 1 82.00 Nociception 1 72.20 Opiate Addiction 1 68.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For LH assays, 0.3 ml blood was collected via an atrial cannula 15 min after drug treatment and every 15 min thereafter for 3 h.

Regulation (collected) of Gene_expression (assays) of LH in blood

1) Confidence 0.45 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6122171 Disease Relevance 0 Pain Relevance 0.56

The failure of ibotenic acid to affect LH-produced descending inhibition when microinjected into the dorsolateral pons, and the significant effect produced by lidocaine microinjected into the same area, implicates fibers of passage in the dorsolateral pons in descending inhibition of the TF reflex produced by focal electrical stimulation in the LH.

Regulation (affect) of Gene_expression (produced) of LH-produced in pons associated with tail-flick and lidocaine

2) Confidence 0.43 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 3249250 Disease Relevance 0.17 Pain Relevance 0.82

[Effect on the administration of LHRH on LH and prolactin plasma levels in adult female rats ovariectomized and maintained in constant light (author's transl)].

Regulation ([Effect) of Gene_expression (levels) of LH in plasma

3) Confidence 0.37 Published 1979 Journal Rev. Esp. Fisiol. Section Title Doc Link 384483 Disease Relevance 0 Pain Relevance 0.07

Effects of LH-RH on serum LH levels were studied during pregnancy in rats.

Regulation (Effects) of Gene_expression (levels) of LH

4) Confidence 0.37 Published 1983 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 6352835 Disease Relevance 0.08 Pain Relevance 0.17

Basal PRL, GH and LH levels and LH, PRL and GH responses to acute METH challenge were not affected by the CD regimen.

Neg (not) Regulation (affected) of Gene_expression (levels) of LH associated with methadone

5) Confidence 0.31 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 4040169 Disease Relevance 0 Pain Relevance 0.99

Basal PRL, GH and LH levels and LH, PRL and GH responses to acute METH challenge were not affected by the CD regimen.

Neg (not) Regulation (affected) of Gene_expression (levels) of LH associated with methadone

6) Confidence 0.31 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 4040169 Disease Relevance 0 Pain Relevance 0.99

To examine further the relationship between the NAL-induced increase in LH release and increase in NPY gene expression, the effects of NPY mRNA antisense oligonucleotides (oligos) on NPY levels in the ME-ARC and on plasma LH levels were studied in NAL-infused rats.

Regulation (effects) of Gene_expression (levels) of LH in plasma associated with aids-related complex and narcan

7) Confidence 0.30 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.28 Pain Relevance 0.65

Surprisingly, we found that naloxone did not reverse the effects of morphine on serum LH levels in the prepubescent animal, although it fully reversed this effect in adults.

Neg (not) Regulation (effects) of Gene_expression (levels) of LH associated with narcan and morphine

8) Confidence 0.27 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8380870 Disease Relevance 0.07 Pain Relevance 1.41

The next study examined the effects of anesthetic drugs on LH response produced by ICV infusions of 45 micrograms of NE.

Spec (examined) Regulation (effects) of Gene_expression (produced) of LH associated with intracerebroventricular

9) Confidence 0.24 Published 1989 Journal Brain Res. Section Abstract Doc Link 2644003 Disease Relevance 0 Pain Relevance 0.43

Effects of bromocriptine and naloxone on plasma levels of prolactin, LH and FSH during suckling in the female rat: responses to gonadotrophin releasing hormone.

Regulation (Effects) of Gene_expression (levels) of LH in plasma associated with narcan

10) Confidence 0.22 Published 1984 Journal J. Endocrinol. Section Title Doc Link 6420492 Disease Relevance 0 Pain Relevance 0.44

A phenobarbital (PHB) injection (100 mg/kg, sc) at 1900 hr on D1 initiated daily PRL surges, which were similar to those observed following cervical stimulation though of less magnitude, without altering the levels of LH and FSH significantly.

Neg (without) Regulation (altering) of Gene_expression (levels) of LH

11) Confidence 0.19 Published 1980 Journal Endocrinol. Jpn. Section Abstract Doc Link 6780329 Disease Relevance 0 Pain Relevance 0.07

No induction in the pPVN was observed 1 and 3 days after thyroidectomy, and no effects attributable specifically to thyroidectomy (as opposed to stress) on Fos expression in the mPVN, AH, LH, or pyriform cortex were observed.

Neg (no) Regulation (effects) of Gene_expression (expression) of LH in cortex associated with stress

12) Confidence 0.11 Published 1991 Journal Endocrinology Section Abstract Doc Link 1954900 Disease Relevance 0.20 Pain Relevance 0.13

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