INT222024

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk8, Mapk14) cytoplasm (Mapk8, Mapk14) cytosol (Mapk8, Mapk14)
nucleus (Mapk8, Mapk14) kinase activity (Mapk8, Mapk14) cell morphogenesis (Mapk14)
Mapk8 (Mus musculus)
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 104 98.96 Very High Very High Very High
Hippocampus 9 95.84 Very High Very High Very High
Inflammation 18 88.28 High High
Anterior cingulate cortex 34 80.52 Quite High
nMDA receptor 14 57.56 Quite High
Calcium channel 1 52.96 Quite High
cytokine 4 52.52 Quite High
Glutamate 1 47.56 Quite Low
Glutamate receptor 1 35.44 Quite Low
dopamine receptor 1 33.96 Quite Low
Disease Link Frequency Relevance Heat
Lung Injury 58 99.84 Very High Very High Very High
INFLAMMATION 18 88.28 High High
Sprains And Strains 4 70.80 Quite High
Injury 9 70.04 Quite High
Necrosis 3 53.12 Quite High
Cancer 2 52.76 Quite High
Pain 5 21.44 Low Low
Death 7 13.92 Low Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Pulmonary Edema 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further assess the role of p38 MAPK and JNK1 in VILI, we ventilated mice genetically deficient either in mkk3 (mkk3?
JNK1 Regulation (role) of p38 MAPK associated with lung injury
1) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.83 Pain Relevance 0.10
In the present study, JNK [28] or p38 inhibitor [29] blocked the induction of cingulate LTP generated by the pairing protocol, indicating that JNK and p38 would be involved in the induction of cingulate LTP.
JNK Regulation (involved) of p38 associated with long-term potentiation
2) Confidence 0.12 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.69

General Comments

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