INT222078

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.77
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Dnajb1) protein folding (Dnajb1) nucleus (Dnajb1)
response to stress (Dnajb1) cytoplasm (Dnajb1)
Anatomy Link Frequency
fibroblasts 2
Dnajb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 29 92.24 High High
Neurotransmitter 1 71.84 Quite High
fibrosis 9 62.96 Quite High
Central nervous system 28 5.00 Very Low Very Low Very Low
Action potential 15 5.00 Very Low Very Low Very Low
TRP channel 12 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Potency 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 6 100.00 Very High Very High Very High
Paralysis 2 82.64 Quite High
Cystic Fibrosis 9 63.52 Quite High
Lysosomal Storage Diseases 96 62.88 Quite High
Targeted Disruption 4 60.04 Quite High
Death 2 50.44 Quite High
Blindness 1 49.64 Quite Low
Neurodegenerative Disease 8 35.60 Quite Low
Lysosome Storage Disease 24 33.28 Quite Low
Creutzfeldt Jakob Disease 1 6.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Positive_regulation (increased) of Gene_expression (expression) of Hsp40
1) Confidence 0.10 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
These increases in molecular chaperone expression levels, especially the cytoplasmic Hsp40 levels, seem to account for the increased GC folding capacity of the ER, and the requirement for new transcription may also contribute to the relatively slow increases in lysosomal enzyme levels upon calcium channel blocker treatment.
Positive_regulation (increases) of Gene_expression (levels) of Hsp40 associated with calcium channel
2) Confidence 0.07 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0.06 Pain Relevance 0.05
The increased protein expression levels of BiP, Hsp40, and Hsp90 were confirmed after a 7-d treatment with diltiazem.
Positive_regulation (increased) of Gene_expression (expression) of Hsp40
3) Confidence 0.07 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0.03
A strictly analogous RT-PCR analysis of N370S/V394L GC fibroblasts reveals similarly increased mRNA expression levels of Hsp40, however BiP and Hsp90 exhibit less of an increase after 7 d of diltiazem treatment (Figure S5).
Positive_regulation (increased) of Gene_expression (expression) of Hsp40 in fibroblasts
4) Confidence 0.07 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
Following activation of the heat shock response, another member of the J protein family, Hsp40 (heat shock protein of 40kDa) assembles with the CSP?
Positive_regulation (activation) of Gene_expression (assembles) of Hsp40 associated with shock
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883571 Disease Relevance 0.70 Pain Relevance 0.10

General Comments

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