INT222400

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.82
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
macrophage 2
pituitary 2
bile 2
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 129 100.00 Very High Very High Very High
Opioid 69 100.00 Very High Very High Very High
Bile 4 100.00 Very High Very High Very High
antagonist 93 99.40 Very High Very High Very High
IPN 19 99.40 Very High Very High Very High
imagery 4 93.24 High High
agonist 59 88.64 High High
Enkephalin 44 84.48 Quite High
Arthritis 30 81.08 Quite High
Pain 30 79.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 150 100.00 Very High Very High Very High
Inflammatory Pain 19 99.40 Very High Very High Very High
Arthritis 42 91.84 High High
Stress 97 88.28 High High
Pain 31 79.92 Quite High
Rheumatoid Arthritis 33 78.68 Quite High
Nociception 24 75.00 Quite High
Osteoarthritis 1 37.68 Quite Low
Increased Venous Pressure Under Development 3 10.20 Low Low
Diabetes Mellitus 7 8.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The FPR antagonists Boc-FLFLF and cyclosporine H reduced opioid peptide release in vitro and increased inflammatory pain in vivo while TLR 2/4 did not appear to be involved.
Negative_regulation (reduced) of Localization (release) of in vitro associated with ipn, antagonist and opioid
1) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2657213 Disease Relevance 0.78 Pain Relevance 1.81
This property correlated with RU-mediated inhibition of murine macrophage activation and inflammatory mediator release in vitro (Figures 3 and 4).
Negative_regulation (inhibition) of Localization (release) of in vitro in macrophage associated with inflammation
2) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.73 Pain Relevance 0.46
Addition of annexin-1 to cultured pituitary cells inhibits CRH-stimulated ACTH secretion, whereas the early inhibitory effects of the steroid on secretagogue-stimulated ACTH release in vitro and in vivo are prevented by blocking synthesis of annexin-1 with antisense oligodeoxynucleotides or by blocking the activity of annexin-1 with anti-annexin-1 antiserum.
Negative_regulation (effects) of Localization (release) of in vivo in pituitary
3) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.16 Pain Relevance 0.04
Interestingly, annexin-1 also appears to inhibit the secretion of PRL, GH, LH and TSH in vitro (750).
Spec (appears) Negative_regulation (inhibit) of Localization (secretion) of in vitro
4) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.14 Pain Relevance 0.03
In vitro release of insulin, a model peptide, from liposomes in the bile salts solution was markedly reduced by coating the surface with the sugar chain portion of mucin or polyethylene glycol.
Negative_regulation (reduced) of Localization (release) of In vitro in bile associated with bile
5) Confidence 0.00 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0.12

General Comments

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