INT222509

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ghrh, Prl) extracellular space (Ghrh)
Anatomy Link Frequency
thyroid 2
Ghrh (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 26 81.84 Quite High
Somatostatin 12 80.80 Quite High
cytokine 44 62.88 Quite High
antagonist 78 52.08 Quite High
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 54 5.00 Very Low Very Low Very Low
agonist 44 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 34 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
gABA 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 44 61.20 Quite High
Infection 2 60.60 Quite High
Stress 96 55.76 Quite High
INFLAMMATION 56 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low
Starvation 20 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Natriuresis 14 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the coaggregates, thyroid-releasing hormone (TRH) stimulated PRL release, as expected, but did not affect LH or FSH release, indicating that the gonadotroph-lactotroph communication is not a random bidirectional communication.
thyroid-releasing hormone Neg (not) Positive_regulation (stimulated) of Localization (release) of PRL in thyroid
1) Confidence 0.28 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.05
When a dispersed cell preparation consisting of approximately 65% FS cells was coaggregated with a highly enriched populations of hormone-secreting cells and the coaggregates, after 5 days in culture, were perifused with various secretagogues, the stimulation of PRL release by TRH or angiotensin II, of GH release by GHRH and adrenaline, and of LH release by GnRH, was blunted, compared to aggregates consisting of the hormonal cells only (94).
GHRH Positive_regulation (stimulation) of Localization (release) of PRL
2) Confidence 0.19 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.23 Pain Relevance 0.11

General Comments

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