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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.03
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
Macrophages 1
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 99.32 Very High Very High Very High
cytokine 113 98.96 Very High Very High Very High
Inflammation 172 97.28 Very High Very High Very High
spastic colon 34 92.56 High High
noradrenaline 4 85.76 High High
Inflammatory response 16 80.04 Quite High
Catecholamine 2 74.96 Quite High
nud 6 74.08 Quite High
antagonist 79 70.72 Quite High
Visceral pain 1 65.28 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 61 99.92 Very High Very High Very High
Sepsis 63 98.42 Very High Very High Very High
Shock 2 97.68 Very High Very High Very High
Bacterial Infection 3 97.36 Very High Very High Very High
INFLAMMATION 181 97.28 Very High Very High Very High
Demyelinating Disease 78 95.80 Very High Very High Very High
Obesity 28 95.08 Very High Very High Very High
Syndrome 8 94.84 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

34 92.56 High High
Infection 47 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tlr4 found on cell surfaces recognizes envelope proteins and lipopolysaccharides.
Tlr4 Binding (recognizes) of
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.16 Pain Relevance 0.03
After incubation with TLR2, TLR4, I?
TLR4 Binding (After) of
2) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0 Pain Relevance 0
Moreover, in addition to bacterial components, fatty acids [60], [61] and opioids [62] have recently been shown to interact with TLR4 at least.
TLR4 Binding (interact) of associated with opioid
3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.82 Pain Relevance 0.74
Fig. 3 shows that sepsis induced TLR4 protein levels and activation, as demonstrated by an increase in TLR4/MyD88 interaction in the three tissues investigated, and atorvastatin reduced this early step of TLR4 activation and also TLR4 expression (Fig. 3A–C).
TLR4 Binding (interaction) of associated with sepsis
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.92 Pain Relevance 0.20
Macrophages interact with endotoxins via Toll-like receptor 4 and are one of the major sources of proinflammatory cytokines in endotoxic shock [28-30].
Toll-like receptor 4 Binding (interact) of in Macrophages associated with bacterial infection and cytokine
5) Confidence 0.14 Published 2008 Journal Respir Res Section Body Doc Link PMC2584635 Disease Relevance 0.73 Pain Relevance 0.26
LPS is recognized by toll-like receptor 4 (TLR4), which acts in concert with the cluster of differentiation 14 (CD14) protein.
TLR4 Binding (recognized) of
6) Confidence 0.12 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892605 Disease Relevance 0.30 Pain Relevance 0.03
FS cells express CD14, which binds the LPS/LPS-binding protein complex and Toll-like receptor type 4, which transduces the LPS signal (689).
Toll-like receptor type 4 Binding (binding) of
7) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.32 Pain Relevance 0.36
FS cells express CD14, which binds the LPS/LPS-binding protein complex and Toll-like receptor type 4, which transduces the LPS signal (689).
Toll-like receptor type 4 Binding (binds) of
8) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.37 Pain Relevance 0.36

General Comments

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