INT222684

Context Info Confidence 0.01 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0.05

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC) plasma membrane (PROC) nucleus (TEAD1) DNA binding (TEAD1)

TEAD1 (Homo sapiens) PROC (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 1 98.92 Central nervous system 13 5.00 cva 9 5.00 Pain 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 1 98.92 Sepsis 23 95.20 Hemorrhage 57 77.12 Death 8 58.96 Multiple Organ Failure 1 42.48 Cv General 3 Under Development 6 5.00 Gastrointestinal Hemorrhage 2 5.00 Ecchymosis 2 5.00 Critical Illness 1 5.00 Thrombocytopenia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A number of studies have demonstrated that DrotAA exerts an anticoagulant effect through inactivation of coagulation factors Va and VIIIa [1], an anti-inflammatory effect [2] and a profibrinolytic effect [3], as well as antiapoptotic [4] and cytoprotective effects [5].

DrotAA Negative_regulation (inactivation) of factors associated with inflammation

1) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2230610 Disease Relevance 0.39 Pain Relevance 0.05

General Comments

This test has worked.