INT22269

Context Info Confidence 0.50 First Reported 1981 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 32 Total Number 37 Disease Relevance 1.71 Pain Relevance 1.95

extracellular region (IGKV1-5)

Anatomy Link Frequency neurons 5 neural 2 plasma 1 brain 1 LGN 1 IGKV1-5 (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 63 100.00 primary somatosensory cortex 50 100.00 antinociception 10 100.00 intrathecal 2 99.74 Spinal cord 3 99.08 Adelta 1 97.36 antagonist 2 97.08 Somatic pain 1 91.20 dexamethasone 4 85.24 cerebral cortex 13 84.16

Disease Link Frequency Relevance Heat Ganglion Cysts 32 98.72 Hypertension 4 79.60 Optic Nerve Injuries 70 78.72 Overactive Bladder 3 76.92 Injury 38 75.68 Referred Pain 1 75.00 Cognitive Disorder 27 72.68 Nicotine Addiction 1 71.44 Adhesions 51 69.12 Reprotox - General 2 31 64.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There was a significant negative correlation between FPQ scores and Eso-PT on V1 (r = -0.57, P = 0.05).

Gene_expression (scores) of V1

1) Confidence 0.50 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20023227 Disease Relevance 0.24 Pain Relevance 0.32

Finally, aside from dorsal V4, the retinotopic organization of macaque early visual cortex (V1, V2, V3, V3A, and ventral V4) is remarkably similar to that observed in human fMRI studies.

Gene_expression (organization) of V1 in ventral

2) Confidence 0.41 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12917375 Disease Relevance 0 Pain Relevance 0.04

As expected, strong activation of non-lesioned parts of V1 was preserved throughout the course of our experiments, whereas inside the lesioned V1 area coherence remained consistently at noise levels (?

Gene_expression (parts) of V1

3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0

Confirming the observation of a preserved cortical organization in a human blindsight subject [30], our data from V1 lesioned monkeys also demonstrate that the retinotopic structure of V1 cortex surrounding the lesion has not changed (Figure 4).

Gene_expression (lesioned) of V1 in cortex

4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0

Note the excellent correspondence between the eccentricities in the part of V1 to be lesioned (V1 region between the arrowheads) and the LPZ in area V2.

Gene_expression (region) of V1

5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0

As expected, strong activation of non-lesioned parts of V1 was preserved throughout the course of our experiments, whereas inside the lesioned V1 area coherence remained consistently at noise levels (?

Gene_expression (area) of V1

6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0

Characterization of the V1 lesion

Gene_expression (lesion) of V1

7) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0.08 Pain Relevance 0.04

An important question that remains is whether higher cortical areas, particularly those with fast response latencies (such as V5/MT or FEF) play a role in generating the persisting activity in areas V2, V3 after V1 lesions.

Gene_expression (lesions) of V1

8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0

To investigate whether the retinotopic organization of areas V1, V2, V3 is changed (e.g. reorganized) after V1 lesioning, we compared visual eccentricity versus cortical distance plots (Materials and Methods) across these areas both in the lesioned and the intact hemispheres.

Gene_expression (lesioning) of V1

9) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0

Note that despite the V1 lesion, significant visually driven modulation remains in both the V2 and V3 LPZ.

Gene_expression (lesion) of V1

10) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0

Monitoring the LPZ activity over time starting one month following the V1 lesion did not reveal systematic changes in BOLD signal amplitude.

Gene_expression (lesion) of V1

11) Confidence 0.32 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2677457 Disease Relevance 0.06 Pain Relevance 0

Similar to the extent of the V1 lesion, the LPZs in V2 and V3 covered an area equal to ?

Gene_expression (lesion) of V1

12) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0

Moreover, there is evidence from EBS studies in animals that the electrical stimulation of V1 produces a change of activity in neural structures that are known to be connected with the V1 (e.g., areas V2, V3, and MT) (Tolias et al., 2005).

Gene_expression (produces) of V1 in neural

13) Confidence 0.30 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2889679 Disease Relevance 0.07 Pain Relevance 0

Moreover, there is evidence from EBS studies in animals that the electrical stimulation of V1 produces a change of activity in neural structures that are known to be connected with the V1 (e.g., areas V2, V3, and MT) (Tolias et al., 2005).

Gene_expression (connected) of V1 in neural

14) Confidence 0.29 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2889679 Disease Relevance 0.07 Pain Relevance 0

They used a model with the following form to explain the responses of V1 neurons to plaid stimuli made of two superimposed sinusoidal gratings:(1)

Gene_expression (neurons) of V1 in neurons

15) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645695 Disease Relevance 0 Pain Relevance 0

There were good correlations between UV (corrected for dose) and the reciprocals of V1, Vdbeta, Vss, and plasma clearance of thiopental.

Gene_expression (reciprocals) of V1 in plasma

16) Confidence 0.16 Published 1981 Journal Anesthesiology Section Abstract Doc Link 7235275 Disease Relevance 0 Pain Relevance 0

This analysis did confirm the expression of v1 (EU562295) and identified another alternatively spliced variant v3 (EU562297) which is widely expressed in adult tissues (Fig. 1D).

Gene_expression (expression) of v1

17) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0 Pain Relevance 0

-RACE product of brain and testis as template and primers specific to v1 (v1F/R4 and v1F0/R4; Fig. 1C right panel), to check whether v1 was expressed in normal tissues.

Gene_expression (expressed) of v1 in brain

18) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0 Pain Relevance 0

We further assessed its expression in 33 normal human adult and fetal tissues by semi-quantitative PCR with specific primers targeting the v1, v2, or common exons (exon 2 and 3) (Fig. 1B), respectively.

Gene_expression (targeting) of v1

19) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0 Pain Relevance 0

Our results also reveal that OPCML transcripts v1 and v2 have different tissue expression patterns.

Gene_expression (expression) of v1

20) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.41 Pain Relevance 0

General Comments

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