INT222788

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL4, MR1) extracellular space (IL4) endoplasmic reticulum (MR1)
plasma membrane (MR1)
Anatomy Link Frequency
monocytes 4
IL4 (Homo sapiens)
MR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 30 99.96 Very High Very High Very High
Inflammation 2 67.48 Quite High
lidocaine 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 132 98.44 Very High Very High Very High
Dengue 30 84.80 Quite High
INFLAMMATION 2 67.48 Quite High
Disease Progression 2 35.92 Quite Low
Flavivirus Infection 14 30.88 Quite Low
Sprains And Strains 14 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 Very Low Very Low Very Low
Asthma 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surface expression of both MR and DC-SIGN is upregulated on MDMØ by IL-4 treatment (Figure 6A and 6B), consistent with previous data for DC-SIGN on human monocytes [20] and for MR on primary mouse MØ [19,21].
IL-4 Positive_regulation (upregulated) of Gene_expression (expression) of MR in monocytes
1) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.43 Pain Relevance 0
We also show that pre-treatment of primary human monocytes with Th2 cytokines (IL-4/IL-13), which upregulate MR expression, increases their susceptibility to DV infection in vitro.
IL-4 Positive_regulation (upregulate) of Gene_expression (expression) of MR in monocytes associated with infection and cytokine
2) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.53 Pain Relevance 0.08

General Comments

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