INT222903

Context Info Confidence 0.60 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 20 Total Number 21 Disease Relevance 8.77 Pain Relevance 1.90

signal transduction (TLR1) plasma membrane (TLR1) intracellular (TLR1)

Anatomy Link Frequency epithelial cell 4 plasma 1 macrophages 1 dendritic cells 1 pneumocytes 1 TLR1 (Homo sapiens)

Pain Link Frequency Relevance Heat psoriasis 57 99.72 Inflammation 176 97.00 Inflammatory response 105 91.28 cytokine 228 90.88 chemokine 41 88.64 corticosteroid 14 80.72 metalloproteinase 4 68.00 dexamethasone 2 64.24 agonist 23 49.28 adenocard 5 26.80

Disease Link Frequency Relevance Heat Atherosclerosis 24 99.88 Psoriasis 81 99.72 Nasopharynx Cancer 103 99.68 Lung Cancer 11 99.36 Diabetes Mellitus 51 98.12 Cancer 308 97.80 Melanoma 14 97.68 Granuloma 3 97.20 INFLAMMATION 287 97.00 Pressure And Volume Under Development 69 96.84

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Anatomy

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Speculation

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Immunofluorescence studies of TLR1, 2, 3, 4 and 5 proteins in human corneal, limbal, and conjunctival tissues showed both plasma membrane and cytoplasmic localization of these proteins (Figure 2).

Gene_expression (studies) of TLR1 in plasma

1) Confidence 0.60 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0

We consistently found the expression of TLR1, 2, 3, and 5 genes and the protein in cultured limbal and conjunctival cell sample.

Gene_expression (expression) of TLR1

2) Confidence 0.54 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.13 Pain Relevance 0.07

In the present experiments, the expression and function of TLR1-10 in both primary cultured and uncultured conjunctival epithelial cells as well as primary cultured limbal epithelial cells were studied.

Gene_expression (expression) of TLR1 in epithelial cells

3) Confidence 0.54 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.08 Pain Relevance 0.04

In humans, there are 11 members of the TLR family (TLR1-TLR11) which are found in a wide variety of cells including epithelial cells and those from the immune system such as neutrophils, macrophages and dendritic cells [2].

Gene_expression (found) of TLR1-TLR11 in macrophages

4) Confidence 0.54 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.09 Pain Relevance 0.13

At the molecular level, the defect in 1805G signaling is likely due to a failure to express or retain TLR1 on the cell surface.

Gene_expression (express) of TLR1

5) Confidence 0.51 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2330092 Disease Relevance 0.32 Pain Relevance 0

Expression of TLR1, 2, 3, 5, and 6 was found in all conjunctival and limbal epithelial cell samples analyzed by real time PCR and western blot.

Gene_expression (Expression) of TLR1 in epithelial cell

6) Confidence 0.47 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0

TLR1-10 gene expression in normal bulbar conjunctival epithelial cells (removed by nitrocellulose paper; n=5), corneal epithelial cells (removed by PALM laser microdissection; n=2; referred to as uncultured cells), and six different primary cultured human conjunctival and limbal epithelial cell samples of each (isolated from different donors) was determined by Taqman real-time PCR analysis.

Gene_expression (expression) of TLR1 in epithelial cell

7) Confidence 0.47 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0.03

TLR1, TLR2, and TLR4 expression was found on lymphocytes, myeloid cells and type II pneumocytes from granulomas of TB patients by immunocytochemistry, whereas TLR9 expression was restricted to macrophages and lymphocytes [23].

Gene_expression (expression) of TLR1 in pneumocytes associated with granuloma

8) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.72 Pain Relevance 0.06

For example, human peripheral blood monocytes and macrophages from lung tissue or colon express TLR1, TLR2, TLR3, TLR4 and TLR5 [20], whereas gut epithelial cells express TLR3 and TLR5 only [21].

Gene_expression (express) of TLR1 in epithelial cells

9) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.74 Pain Relevance 0.10

Recent work (23) has shown that in atherosclerosis, the expression of TLR1, -2, and -4 in the arterial intima is increased, especially in areas with inflammatory infiltration.

Gene_expression (expression) of TLR1 associated with inflammation and atherosclerosis

10) Confidence 0.31 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 1.01 Pain Relevance 0.26

The TIL were washed three times in PBS and cultured in KBM-400 lymphocyte medium for 2 weeks.

Gene_expression (washed) of TIL in lymphocyte

11) Confidence 0.27 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2613411 Disease Relevance 0.86 Pain Relevance 0.03

Insulin infusion suppressed the mRNA expression of TLR1, -2, -4, -7, and -9 in MNCs within 2 h, with a maximum fall at 4 h by 24 ± 9%, 21 ± 5%, 30 ± 8%, 28 ± 5%, and 27 ± 10%, respectively, below baseline (P < 0.05 for all) (Fig. 1).

Gene_expression (expression) of TLR1

12) Confidence 0.27 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.10 Pain Relevance 0

Our data clearly show for the first time a potent and rapid suppressive effect of a low dose of insulin infusion on the expression of TLR1, -2, -4, -7, and -9 by 20–30%, evident at 2 h, continuing until 4 h, and reverting back to baseline 2 h after the cessation of infusion.

Gene_expression (expression) of TLR1

13) Confidence 0.24 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.08 Pain Relevance 0.04

In humans, there are 11 members of the TLR family (TLR1-TLR11) which are found in a wide variety of cells including epithelial cells and those from the immune system such as neutrophils, macrophages and dendritic cells [2].

Gene_expression (found) of TLR1-TLR11 in neutrophils

14) Confidence 0.18 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.09 Pain Relevance 0.13

In humans, there are 11 members of the TLR family (TLR1-TLR11) which are found in a wide variety of cells including epithelial cells and those from the immune system such as neutrophils, macrophages and dendritic cells [2].

Gene_expression (found) of TLR1-TLR11 in dendritic cells

15) Confidence 0.18 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.09 Pain Relevance 0.13

for NPC have also been detected with polymorphism in toll-like receptor 1, 6, 10,

Gene_expression (detected) of toll-like receptor 1 associated with nasopharynx cancer

16) Confidence 0.16 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.91 Pain Relevance 0

In regard to TLR expression, keratinocytes in the epidermis constitutively express TLR 1, 2, and 5.

Gene_expression (express) of TLR 1 in epidermis

17) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.84 Pain Relevance 0.22

In psoriasis lesions, the expression of TLR 1 and TLR 2 on keratinocytes is further upregulated [62].

Gene_expression (expression) of TLR 1 in keratinocytes associated with psoriasis

18) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.83 Pain Relevance 0.19

Up to now, the best results for patients with metastatic melanoma have been obtained with adoptive therapy involving lymphodepletion followed by the intravenous injection of exvivo expanded TIL plus IL2.

Gene_expression (expanded) of TIL associated with melanoma

19) Confidence 0.08 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 0.34 Pain Relevance 0.13

When primary human monocytes are treated with ATRA (all-trans retinoic acid), TLR 2 and CD14 are downregulated without any change in expression of TLR 1 and 4 [142].

Gene_expression (expression) of TLR 1 in monocytes

20) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.83 Pain Relevance 0.33

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