INT223464
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
When expressed as "fold-change in expression" the SAGE results demonstrate a down regulation of Grik1, Dock4 and Crip2 expression between P0 WT and P0 Trka-/- DRG of about 18, 6 and 3 fold respectively, while QRT-PCR provided an expression ratio between P0 WT and P0 Trka-/- DRG of 17, 4 and 4 fold respectively.
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On the other hand, it has been shown that the transcription factor RunX3 plays an essential role in the establishment of the proprioceptive neuron phenotype [25] and the targeting of proprioceptive (TrkC-expressing) afferents to the ventral region of the spinal cord [9], raising the possibility that Crip2 expression is under the control of this transcriptional program. | |||||||||||||||
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The functional significance of Crip2 expression in DRG neurons remains to be explored, Concerning Grik1/GluR5, our results show unequivocally that, in the adult mouse DRG, this kainate receptor is expressed in the great majority of isolectin B4 binding neurons and is excluded from other neuronal sub-types. | |||||||||||||||
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General Comments
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