INT223464

Context Info Confidence 0.51 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.19 Pain Relevance 0.34

molecular_function (Crip2) cellular_component (Crip2)

Anatomy Link Frequency ventral 2 adult mouse 2 Crip2 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 9 99.30 Trk A 3 92.12 nociceptor 54 59.60 Pain 15 59.12 Glutamate receptor 6 56.64 Neuropeptide 9 31.84 sodium channel 3 29.76 dorsal root ganglion 6 5.00 Congenital analgesia 3 5.00 Central nervous system 3 5.00

Disease Link Frequency Relevance Heat Nociception 24 65.12 Targeted Disruption 3 62.92 Pain 15 59.12 Neuroblastoma 3 36.72 Ganglion Cysts 6 5.00 Hypersensitivity 6 5.00 Syndrome 3 5.00 Decapitation 3 5.00 Injury 3 5.00 INFLAMMATION 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When expressed as "fold-change in expression" the SAGE results demonstrate a down regulation of Grik1, Dock4 and Crip2 expression between P0 WT and P0 Trka-/- DRG of about 18, 6 and 3 fold respectively, while QRT-PCR provided an expression ratio between P0 WT and P0 Trka-/- DRG of 17, 4 and 4 fold respectively.

Regulation (regulation) of Gene_expression (expression) of Crip2

1) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.13 Pain Relevance 0.16

On the other hand, it has been shown that the transcription factor RunX3 plays an essential role in the establishment of the proprioceptive neuron phenotype [25] and the targeting of proprioceptive (TrkC-expressing) afferents to the ventral region of the spinal cord [9], raising the possibility that Crip2 expression is under the control of this transcriptional program.

Regulation (under) of Gene_expression (expression) of Crip2 in ventral associated with spinal cord

2) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.05

The functional significance of Crip2 expression in DRG neurons remains to be explored, Concerning Grik1/GluR5, our results show unequivocally that, in the adult mouse DRG, this kainate receptor is expressed in the great majority of isolectin B4 binding neurons and is excluded from other neuronal sub-types.

Regulation (significance) of Gene_expression (expression) of Crip2 in adult mouse

3) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.06 Pain Relevance 0.13

General Comments

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