INT223497

Context Info Confidence 0.19 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.50 Pain Relevance 0.05

molecular_function (Erv4) cellular_component (Erv4) biological_process (Erv4)

Erv4 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 4 91.88 Multiple sclerosis 6 25.36 anesthesia 16 10.48 Inflammation 4 5.00 Demyelination 2 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Burns 182 98.70 Stress 26 93.52 Rheumatoid Arthritis 4 91.88 Systemic Lupus Erythematosus 4 90.88 Autoimmune Disease 8 89.40 Injury 10 45.08 Disease 14 44.72 Demyelinating Disease 8 25.36 INFLAMMATION 6 5.00 Schizophrenia 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further investigation is needed to understand the role of these MuERVs in post-burn systemic pathogenesis, in particular, via characterization of their interaction with host genes, MuERV gene products, and viral activities.

MuERV Binding (interaction) of associated with burns

1) Confidence 0.19 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC2241634 Disease Relevance 0.59 Pain Relevance 0

An investigation into the role of the U-4-11.1 putative MuERV in the transcriptional control of IgG Fc receptor genes after burn, especially the Fcgr3a gene, will allow us to better understand interactions between this MuERV locus and nearby IgG Fc receptors.

MuERV Binding (interactions) of associated with burns

2) Confidence 0.16 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2241634 Disease Relevance 0.91 Pain Relevance 0.05

General Comments

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