INT223920

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.40
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina1) extracellular region (Serpina1)
Serpina1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 332 100.00 Very High Very High Very High
monoamine 52 99.08 Very High Very High Very High
agonist 44 96.32 Very High Very High Very High
fluoxetine 44 86.12 High High
Desipramine 24 85.64 High High
Hippocampus 16 78.96 Quite High
depression 76 77.36 Quite High
Potency 4 60.76 Quite High
sSRI 32 45.28 Quite Low
Dopamine 8 14.68 Low Low
Disease Link Frequency Relevance Heat
Toxicity 4 96.32 Very High Very High Very High
Urological Neuroanatomy 8 84.48 Quite High
Depression 76 77.36 Quite High
Disease 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Affective Disorder 8 5.00 Very Low Very Low Very Low
Suicidal Behaviour 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
How then might an effect of antidepressant agents on CDP-DG and PI synthesis be associated with the antidepressive efficacy of the compounds?
Regulation (effect) of Gene_expression (synthesis) of PI associated with antidepressant
1) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.39
MAOIs that were effective in inducing CDP-DG production also showed enhanced effects on PI resynthesis (Figure 3), whereas other MAOIs that were ineffective on CDP-DG were equally ineffective in increasing PI resynthesis (data not shown).
Regulation (effects) of Gene_expression (resynthesis) of PI
2) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.08 Pain Relevance 0.25
Antidepressant-induced CDP-diacylglycerol formation partially depends on PI hydrolysis
Regulation (depends) of Gene_expression (hydrolysis) of PI associated with antidepressant
3) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.41
Effects of monoamine oxidase inhibiting agents CDP-diacylglycerol formation and PI synthesis
Regulation (formation) of Gene_expression (synthesis) of PI associated with monoamine
4) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.15 Pain Relevance 0.53

General Comments

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