INT223923

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.27
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina1) extracellular region (Serpina1)
Serpina1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 249 98.92 Very High Very High Very High
depression 57 95.80 Very High Very High Very High
Potency 3 90.20 High High
Hippocampus 12 78.00 Quite High
fluoxetine 33 74.44 Quite High
sSRI 24 73.96 Quite High
Desipramine 18 72.48 Quite High
monoamine 39 70.12 Quite High
agonist 33 5.00 Very Low Very Low Very Low
Serotonin 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 57 95.80 Very High Very High Very High
Urological Neuroanatomy 6 74.96 Quite High
Disease 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Affective Disorder 6 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Suicidal Behaviour 3 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antidepressant-induced CDP-diacylglycerol formation translates into increased PI synthesis
Positive_regulation (increased) of Gene_expression (synthesis) of PI associated with antidepressant
1) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.72
MAOIs that were effective in inducing CDP-DG production also showed enhanced effects on PI resynthesis (Figure 3), whereas other MAOIs that were ineffective on CDP-DG were equally ineffective in increasing PI resynthesis (data not shown).
Positive_regulation (increasing) of Gene_expression (resynthesis) of PI
2) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.07 Pain Relevance 0.24
Antidepressant-induced CDP-diacylglycerol formation translates into increased PI synthesis
Positive_regulation (increased) of Gene_expression (synthesis) of PI associated with antidepressant
3) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.72

General Comments

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