INT224107

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
NG108-15 2
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 206 100.00 Very High Very High Very High
adenocard 120 98.16 Very High Very High Very High
dopamine receptor 2 32.72 Quite Low
antagonist 34 14.88 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Cannabinoid 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 22 94.40 High High
Necrosis 2 93.84 High High
Disease 12 5.00 Very Low Very Low Very Low
Hypoxia 10 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Neuroblastoma 8 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Bordatella Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stable transfection of a GRK2Lys220Arg mutant in NG108-15 cells reduced desensitization of the A2AR by 50% following a 30-min treatment with the adenosine agonist NECA.
Negative_regulation (reduced) of Negative_regulation (desensitization) of A2AR in NG108-15 associated with adenocard and agonist
1) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.19 Pain Relevance 0.21
However, the resensitization of the A2AR upon agonist removal was abolished in the presence of ConA or sucrose.
Negative_regulation (abolished) of Negative_regulation (resensitization) of A2AR associated with agonist
2) Confidence 0.27 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.13 Pain Relevance 0.27

General Comments

This test has worked.

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