INT224154

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 21
Disease Relevance 22.65
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TREM1) plasma membrane (TREM1) intracellular (TREM1)
Anatomy Link Frequency
lung 2
TREM 1
bowel 1
TREM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 252 99.90 Very High Very High Very High
cytokine 35 98.20 Very High Very High Very High
Inflammatory response 49 96.16 Very High Very High Very High
peptic ulcer disease 14 86.32 High High
Inflammatory mediators 35 82.96 Quite High
alcohol 7 68.12 Quite High
corticosteroid 14 62.92 Quite High
agonist 35 48.96 Quite Low
cva 21 10.20 Low Low
imagery 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 553 100.00 Very High Very High Very High
Myocardial Infarction 21 99.92 Very High Very High Very High
INFLAMMATION 322 99.90 Very High Very High Very High
Sepsis 196 99.28 Very High Very High Very High
Disease 259 98.80 Very High Very High Very High
Pneumonia 273 98.76 Very High Very High Very High
Pancreatitis 7 98.60 Very High Very High Very High
Ulcers 21 97.96 Very High Very High Very High
Ventilator-associated Pneumonia 28 97.84 Very High Very High Very High
Bacterial Meningitis 14 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of TREM-1 leads to the production of pro-inflammatory cytokines [9,31,32].
Positive_regulation (Activation) of TREM-1 associated with inflammation and cytokine
1) Confidence 0.56 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.86 Pain Relevance 0.21
As sTREM-1 can be induced by increased
Positive_regulation (induced) of sTREM-1
2) Confidence 0.52 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.09 Pain Relevance 0.22
A recent study by Richeldi et al. demonstrates that an increase in sTREM-1 is also detectable in
Positive_regulation (increase) of sTREM-1
3) Confidence 0.52 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.27 Pain Relevance 0.11
Few data are available on the diagnostic role of TREM-1 and of sTREM-1 in patients with lung infiltrates.
Positive_regulation (role) of TREM-1 in lung
4) Confidence 0.40 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.83 Pain Relevance 0.21
Few data are available on the diagnostic role of TREM-1 and of sTREM-1 in patients with lung infiltrates.
Positive_regulation (role) of sTREM-1 in lung
5) Confidence 0.40 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.83 Pain Relevance 0.21
Concentrations of sTREM-1 and of CRP in sera of both groups and expression of nTREM-1 and mTREM-1 are given in Table 2.
Positive_regulation (Concentrations) of sTREM-1
6) Confidence 0.40 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 0.99 Pain Relevance 0.07
This same soluble form of TREM-1 seems to be increased in patients bearing non-infectious processes like peptic ulcer, inflammatory bowel disease, viral infections, malignant pleural effusions and chronic obstructive pulmonary disease (COPD) but also among patients after cardiac surgery or cardiac arrest.
Positive_regulation (increased) of TREM-1 in bowel associated with pulmonary disease, inflammation, viral infection, ulcers, malignant pleural effusion and myocardial infarction
7) Confidence 0.37 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 1.96 Pain Relevance 0.23
Increase of sTREM-1 seems particular prominent when the latter non-infectious states are complicated with systemic inflammatory response syndrome (SIRS) without infection [13-19].
Positive_regulation (Increase) of sTREM-1 associated with inflammatory response, systemic inflammatory response syndrome and infection
8) Confidence 0.37 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 1.87 Pain Relevance 0.22
A soluble form of TREM-1, namely sTREM-1, is increased in the bronchoalveolar lavage (BAL) of patients with ventilator associated pneumonia (VAP) [5,6], and in the serum of patients with sepsis, with bacterial meningitis and with acute pancreatitis [7-12].
Positive_regulation (increased) of sTREM-1 in TREM associated with ventilator-associated pneumonia, bacterial meningitis, pancreatitis and sepsis
9) Confidence 0.37 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2955686 Disease Relevance 1.78 Pain Relevance 0.21
In the present study, we show that sTREM-1 levels in serum are elevated in patients with COPD compared to healthy, nonsmoking controls.
Positive_regulation (elevated) of sTREM-1 associated with pulmonary disease
10) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.02 Pain Relevance 0.12
Serum levels of sTREM-1 are elevated in patients with COPD
Positive_regulation (elevated) of sTREM-1 associated with pulmonary disease
11) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.59 Pain Relevance 0
healthy individuals for sTREM-1 and indeed found elevated levels of sTREM-1 in
Positive_regulation (elevated) of sTREM-1
12) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.51 Pain Relevance 0.09
To evaluate the newly developed assay TREM-1-IgG recombinant human TREM-1::IgG1 and serum form a patient with sepsis were analyzed in serial dilutions since high levels of sTREM-1 have been described in sepsis
Spec (analyzed) Positive_regulation (levels) of sTREM-1 associated with sepsis
13) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.41 Pain Relevance 0
ELISA assay could be the reason for increased levels of sTREM-1 detected in the
Positive_regulation (increased) of sTREM-1
14) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.10 Pain Relevance 0.21
In summary we show increased serum levels of sTREM-1
Positive_regulation (increased) of sTREM-1
15) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.08 Pain Relevance 0.13
increased levels of sTREM-1 in serum.
Positive_regulation (increased) of sTREM-1
16) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.19 Pain Relevance 0.16
levels of sTREM-1 were significantly (P=.019) increased in patients with COPD
Positive_regulation (increased) of sTREM-1 associated with pulmonary disease
17) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.63 Pain Relevance 0
systemic inflammation and increased sTREM-1 levels [43, 44].
Positive_regulation (increased) of sTREM-1 associated with inflammation
18) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.27 Pain Relevance 0.15
increased levels of sTREM-1 in patients with sepsis [22], pneumonia [20] but also exacerbated asthma and
Positive_regulation (increased) of sTREM-1 associated with asthma, pneumonia and sepsis
19) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 1.18 Pain Relevance 0.12
In summary, serum concentrations of sTREM-1 are increased in patients with COPD.
Positive_regulation (increased) of sTREM-1 associated with pulmonary disease
20) Confidence 0.35 Published 2007 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2246041 Disease Relevance 0.57 Pain Relevance 0.03

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