INT22448

Context Info Confidence 0.33 First Reported 1990 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 7 Disease Relevance 1.95 Pain Relevance 1.85

isomerase activity (GPI) small molecule metabolic process (GPI) carbohydrate metabolic process (GPI) cytoplasm (GPI) cytosol (GPI) extracellular space (GPI)

Anatomy Link Frequency thalamus 1 central nervous system 1 neural 1 GPI (Homo sapiens)

Pain Link Frequency Relevance Heat Thalamus 126 100.00 substance P 4 100.00 deep brain stimulation 259 99.96 Central nervous system 1 99.76 Somatostatin 4 99.08 Cholecystokinin 3 98.88 Neuropeptide 5 92.64 Spinal cord 7 82.20 anesthesia 1 75.00 Enkephalin 1 72.32

Disease Link Frequency Relevance Heat Parkinson's Disease 127 93.88 Disease 385 92.24 Tremor 55 90.24 Hemolytic Anemia 2 89.52 Death 1 83.56 Gliosis 1 77.84 Dyskinesias 45 68.24 Aging 4 63.76 Dysphagia 2 59.08 Dysarthria 3 58.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, maintaining the flexibility to perform model-based control the STN, GPi or VIM, depending upon a patient’s symptom complex, is a challenge for future work.

Regulation (control) of GPi

1) Confidence 0.33 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.32 Pain Relevance 0.05

We will now extend our model, from the oscillations between the GPe and the STN (Terman et al. 2002), to the effect of these oscillations on the thalamus through the intermediary way station of the GPi.

Regulation (effect) of GPi in thalamus associated with thalamus

2) Confidence 0.29 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.19 Pain Relevance 0.22

To focus on the possible effects of GPI mutations on the central nervous system through an effect on neuroleukin activity, we analysed DNA isolated from two patients with severe GPI deficiency, one of them with additional neurological deficits, and their families.

Regulation (effect) of neuroleukin in central nervous system associated with central nervous system

3) Confidence 0.27 Published 1998 Journal Hum. Genet. Section Abstract Doc Link 9856489 Disease Relevance 0.16 Pain Relevance 0.12

In Rubin & Terman (2004), such an effect can be shown as a slow on and off square-wave modulation of GPi output.

Regulation (modulation) of GPi

4) Confidence 0.17 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.28 Pain Relevance 0.10

Note two things about the effect of stimulation on the GPi activity in figure 6: (i) the frequency is increased and (ii) the neural response becomes less episodic and more continuous.

Regulation (effect) of GPi in neural

5) Confidence 0.17 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0 Pain Relevance 0.14

In rats, a postmortem delay of up to 8 hours did not affect SP, Met-Enk, PHI, or NPY and decreased SST, CCK, and VIP levels.

Neg (not) Regulation (affect) of PHI associated with somatostatin, cholecystokinin and substance p

6) Confidence 0.09 Published 1990 Journal Neurology Section Abstract Doc Link 2296359 Disease Relevance 0.17 Pain Relevance 0.77

The relative safety and efficacy of STN vs GPi DBS, however, has been compared formerly in only small studies (Burchiel et al 1999).

Regulation (efficacy) of GPi associated with deep brain stimulation

7) Confidence 0.06 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 0.83 Pain Relevance 0.46

General Comments

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