INT224481

Context Info Confidence 0.37 First Reported 2007 Last Reported 2010 Negated 0 Speculated 4 Reported most in Body Documents 4 Total Number 8 Disease Relevance 5.07 Pain Relevance 2.74

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)

Anatomy Link Frequency chondrocytes 2 cartilage 2 F2RL1 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 330 99.60 agonist 85 98.08 Inflammation 160 98.00 cytokine 65 97.20 Arthritis 21 88.76 metalloproteinase 120 85.28 rheumatoid arthritis 5 85.20 COX2 17 79.92 Hyperalgesia 15 77.88 Thermal hyperalgesia 5 73.20

Disease Link Frequency Relevance Heat Osteoarthritis 335 99.60 INFLAMMATION 171 98.00 Cancer 62 92.88 Targeted Disruption 9 90.84 Arthritis 21 88.76 Rheumatoid Arthritis 5 85.20 Neurogenic Inflammation 5 81.80 Breast Cancer 2 80.08 Hyperalgesia 20 77.88 Thrombosis 2 74.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Previously, we have shown that Gq/11 plays a positive role in the regulation of PAR2 mediated NF?

Regulation (regulation) of PAR2

1) Confidence 0.37 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0

To explore the mechanism underlying PAR-2 modulation in human OA cartilage, we studied the effects of two proinflammatory cytokines, IL-1?

Regulation (modulation) of PAR-2 in cartilage associated with osteoarthritis and cytokine

2) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.52 Pain Relevance 0.38

We investigated the in situ levels and modulation of PAR-2 in human normal and osteoarthritis (OA) cartilage/chondrocytes.

Spec (investigated) Regulation (modulation) of PAR-2 in cartilage associated with osteoarthritis

3) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.73 Pain Relevance 0.49

This study aimed to investigate the in situ levels and modulation of PAR-2 in human normal and OA cartilage, determine its functional consequences on this tissue, and evaluate the chondrocyte signalling pathways involved in PAR-2 activity.

Spec (investigate) Regulation (modulation) of PAR-2 in chondrocyte associated with osteoarthritis

4) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 1.33 Pain Relevance 0.75

Regulation of PAR-2 synthesis

Regulation (Regulation) of PAR-2

5) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.52 Pain Relevance 0.35

The significance of this new observation for PAR2 activation in terms of cellular and physiological mechanisms remains to be elucidated, but points to the need for studies that investigate PAR2 regulation in both normal metabolism and metabolic dysfunction.

Spec (investigate) Regulation (regulation) of PAR2

6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.85 Pain Relevance 0.19

New PAR2 must therefore be produced in the cell and expressed on the cell surface to account for the observed up-regulation of PAR2 mRNA in response to the two extracellular PAR2 agonists.

Regulation (regulation) of PAR2 associated with agonist

7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.40 Pain Relevance 0.09

We investigated the in situ levels and modulation of PAR-2 in human normal and osteoarthritis (OA) cartilage/chondrocytes.

Spec (investigated) Regulation (modulation) of PAR-2 in chondrocytes associated with osteoarthritis

8) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.73 Pain Relevance 0.49

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