INT224636

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.16
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il21) extracellular region (Il21)
Anatomy Link Frequency
platelet 1
eosinophils 1
basophils 1
mast cells 1
Il21 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 118 100.00 Very High Very High Very High
rheumatoid arthritis 52 100.00 Very High Very High Very High
Crohn's disease 97 97.72 Very High Very High Very High
Inflammation 197 95.48 Very High Very High Very High
chemokine 25 66.16 Quite High
Inflammatory mediators 4 58.80 Quite High
metalloproteinase 25 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 52 100.00 Very High Very High Very High
Inflammatory Bowel Disease 108 99.40 Very High Very High Very High
Genetic Predisposition To Disease 4 99.36 Very High Very High Very High
Diabetes Mellitus 154 98.32 Very High Very High Very High
Disease 191 97.72 Very High Very High Very High
Sprains And Strains 6 96.64 Very High Very High Very High
INFLAMMATION 201 95.48 Very High Very High Very High
Asthma 222 85.08 High High
Worm Infection 6 79.12 Quite High
Infection 3 65.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, induction of IL17A and IL21 was significantly more pronounced in UC than in colonic CD, and this induction was associated with more intense inflammation as defined by increased induction of IL8.
Positive_regulation (induction) of IL21 associated with inflammatory bowel disease, inflammation and crohn's disease
1) Confidence 0.45 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.29 Pain Relevance 0.55
Data suggest a contribution of IL21 and IL21R to a genetic susceptibility to T1D and possible involvement of IL-21 and its receptor system in the disease pathogenesis [42].
Positive_regulation (contribution) of IL21 associated with diabetes mellitus, genetic predisposition to disease and disease
2) Confidence 0.43 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.88 Pain Relevance 0
In UC samples, IL17A (P = 0.0002), IL21 (P = 0.0021), IL22 (P = 0.0003) and IL26 (P = 0.0017) were strongly induced, and IL17F (P = 0.046) was weakly induced, while in colonic CD samples, IL17A (P = 0.0084) and IL22 (P = 0.001) were strongly induced, and IL21 (P = 0.047), IL26 (P = 0.048) and IL17F (P = 0.011) were weakly induced (Figure 2B).
Positive_regulation (induced) of IL21 associated with inflammatory bowel disease and crohn's disease
3) Confidence 0.30 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.54 Pain Relevance 0.53
Th2-type responses are characterized by increases in the levels of interleukin (IL)-4 and other Th2 cytokines (IL-5, IL-9, IL-13, and IL-21), activation and expansion of CD4+ Th2 cells, plasma cells secreting IgE, eosinophils, basophils, and mast cells, all of which can synthesize and release several types of Th2 cytokines [5].
Positive_regulation (increases) of IL-21 in basophils associated with cytokine
4) Confidence 0.08 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.65 Pain Relevance 0.13
For example, the receptor for IL-21 was found to be expressed on RASFs, but mRNA for IL-21 was neither detectable in RA synovium nor inducible by key proinflammatory cytokines and growth factors such as IL-1, TNF, platelet-derived growth factor and TGF.
Neg (nor) Positive_regulation (inducible) of IL-21 in platelet associated with rheumatoid arthritis and cytokine
5) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.49 Pain Relevance 0.49
Th2-type responses are characterized by increases in the levels of interleukin (IL)-4 and other Th2 cytokines (IL-5, IL-9, IL-13, and IL-21), activation and expansion of CD4+ Th2 cells, plasma cells secreting IgE, eosinophils, basophils, and mast cells, all of which can synthesize and release several types of Th2 cytokines [5].
Positive_regulation (increases) of IL-21 in mast cells associated with cytokine
6) Confidence 0.03 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.65 Pain Relevance 0.13
Th2-type responses are characterized by increases in the levels of interleukin (IL)-4 and other Th2 cytokines (IL-5, IL-9, IL-13, and IL-21), activation and expansion of CD4+ Th2 cells, plasma cells secreting IgE, eosinophils, basophils, and mast cells, all of which can synthesize and release several types of Th2 cytokines [5].
Positive_regulation (increases) of IL-21 in eosinophils associated with cytokine
7) Confidence 0.03 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.65 Pain Relevance 0.13

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