INT224648

From wiki-pain
Revision as of 15:17, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 23
Disease Relevance 18.71
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il21) extracellular region (Il21)
Anatomy Link Frequency
Th17 cells 7
ileum 2
T cell 2
colon 1
platelet 1
Il21 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 598 100.00 Very High Very High Very High
Inflammation 548 100.00 Very High Very High Very High
Crohn's disease 440 99.80 Very High Very High Very High
rheumatoid arthritis 234 99.36 Very High Very High Very High
chemokine 54 98.72 Very High Very High Very High
antagonist 10 98.56 Very High Very High Very High
psoriasis 114 96.78 Very High Very High Very High
Arthritis 186 91.80 High High
Inflammatory mediators 24 81.52 Quite High
Inflammatory response 13 60.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 544 100.00 Very High Very High Very High
Disease 741 99.80 Very High Very High Very High
Cancer 43 99.68 Very High Very High Very High
Candida Infection 53 99.52 Very High Very High Very High
Necrosis 14 99.44 Very High Very High Very High
Rheumatoid Arthritis 294 99.36 Very High Very High Very High
Colon Disease 9 98.48 Very High Very High Very High
Inflammatory Bowel Disease 495 98.32 Very High Very High Very High
Psoriasis 140 96.78 Very High Very High Very High
Asthma 431 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of IL17A, IL17F, IL22, IL26, IL21, CCL20 and CCR6 has been found in inflamed colonic tissues of IBD patients [4,14,28-33].
Gene_expression (expression) of IL21 associated with inflammatory bowel disease
1) Confidence 0.39 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.62 Pain Relevance 0.31
In ileal CD samples, IL22 (P = 0.0015) was strongly induced, while IL17A (P = 0.013), IL26 (P = 0.029) and IL17F (P = 0.019) were weakly induced, and expression levels of IL21 were similar to those in ileal controls.
Gene_expression (expression) of IL21 associated with crohn's disease
2) Confidence 0.39 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.84 Pain Relevance 0.52
Tfh cells produce IL-21, which is necessary for GC formation.
Gene_expression (produce) of IL-21 in Tfh
3) Confidence 0.39 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.16 Pain Relevance 0.27
The increased number of ileal controls expressing IL21 could reflect the presence of Peyer's patches in the terminal ileum, where B lymphocytes predominate in the GC.
Gene_expression (expressing) of IL21 in ileum
4) Confidence 0.39 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.06 Pain Relevance 0.24
In CD samples, expression of IL21 (P = 0.0097) was significantly higher in the colon than in the ileum.


Gene_expression (expression) of IL21 in ileum associated with crohn's disease
5) Confidence 0.39 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.93 Pain Relevance 0.53
Although increased expression of IL17A, IL17F, IL21 and IL26 was detected in inflamed ileal samples, expression of the indispensable Th17 cell differentiation factors TGFB1 and IL23A, the signaling molecule STAT3 and the Th17 recruitment factors CCR6 and CCL20 were unchanged.


Gene_expression (expression) of IL21 in Th17 cell
6) Confidence 0.39 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.89 Pain Relevance 0.33
The expression levels of the Th17 effector cytokines IL17A, IL17F, IL21, IL22 and IL26 were comparable between colonic and ileal control samples (Figure 1B); however, the expression of these cytokines in each individual sample was not consistent.
Gene_expression (expression) of IL21 associated with cytokine
7) Confidence 0.39 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.45 Pain Relevance 0.49
Furthermore, in the colon, expression levels of IL17A (P = 0.005) and IL21 (P = 0.036) were significantly higher in UC samples than in CD samples.
Gene_expression (expression) of IL21 in colon associated with inflammatory bowel disease and crohn's disease
8) Confidence 0.39 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 2.02 Pain Relevance 0.57
The present study assessed the mRNA expression levels of Th17 effector cytokines (IL17A, IL17F, IL21, IL22 and IL26) and genes involved in differentiation (IL6, IL1B, TGFB1, IL23A and STAT3) and recruitment of Th17 cells (CCR6 and CCL20) by quantitative real-time PCR analysis of colonic and ileal biopsies from 22 healthy control subjects, 26 patients with Crohn's disease (CD) and 12 patients with ulcerative colitis (UC).
Gene_expression (expression) of IL21 in Th17 cells associated with inflammatory bowel disease, crohn's disease, disease and cytokine
9) Confidence 0.39 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.88 Pain Relevance 0.34
Most recently, another T helper cells population has been described that produce not only IL-17A, IL-21, and IL-22 but also considerable amounts of the typical TH2-type cytokines IL-4, IL-5, and IL-13.
Gene_expression (produce) of IL-21 associated with cytokine
10) Confidence 0.16 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.76 Pain Relevance 0.05
IL-21 is a cytokine produced by activated CD4+ T cells that also signals through JAK3.
Gene_expression (produced) of IL-21 in T cells associated with cytokine
11) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 1.01 Pain Relevance 0.52
In addition to IL-17, Th17 cells have been shown to produce IL-21, IL-22, TNF?
Gene_expression (produce) of IL-21 in Th17 cells
12) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.85 Pain Relevance 0.35
IL-21 belongs to the IL-2 cytokine superfamily and is produced by several T cell subpopulations such as TH2 cells, follicular B helper T cells, and TH17 cells, while the last appears to produce the largest amounts [100–103].
Gene_expression (produced) of IL-21 in T cell associated with cytokine
13) Confidence 0.11 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.53 Pain Relevance 0.29
, IL-21 and IL-23 in Th17 development has been clearly established, less is known about physiological antagonists of Th17 responses.
Gene_expression (established) of IL-21 associated with antagonist
14) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0.08 Pain Relevance 0.10
Th2-type responses are characterized by increases in the levels of interleukin (IL)-4 and other Th2 cytokines (IL-5, IL-9, IL-13, and IL-21), activation and expansion of CD4+ Th2 cells, plasma cells secreting IgE, eosinophils, basophils, and mast cells, all of which can synthesize and release several types of Th2 cytokines [5].
Gene_expression (synthesize) of IL-21 in basophils associated with cytokine
15) Confidence 0.10 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.78 Pain Relevance 0.14
IL-21 can be produced by Th17 cells [39, 71] and can also be involved in Th17 polarization since in the absence of IL-6, IL-21 in combination with TGF-beta could function as an alternative signal for the induction of Th17 cells [39].
Gene_expression (produced) of IL-21 in Th17 cells
16) Confidence 0.08 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.77 Pain Relevance 0.38
IL-6 induces B-cell differentiation through its action on plasmablasts [16] and more recently has been shown to induce B-cell antibody production indirectly by promoting the B-cell helper properties of CD4+ T cells via the production of IL-21 [17].
Gene_expression (production) of IL-21 in B-cell
17) Confidence 0.08 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.60 Pain Relevance 0.14
For example, the receptor for IL-21 was found to be expressed on RASFs, but mRNA for IL-21 was neither detectable in RA synovium nor inducible by key proinflammatory cytokines and growth factors such as IL-1, TNF, platelet-derived growth factor and TGF.
Gene_expression (expressed) of IL-21 in platelet associated with rheumatoid arthritis and cytokine
18) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.48 Pain Relevance 0.49
, IL-6, and IL-23, resulting in Th17 cell expression of IL-6, IL-17, IL-21, IL-22, IFN-?
Gene_expression (expression) of IL-21 in Th17 cell
19) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.61 Pain Relevance 0.31
As a newly developed, targeted biological agent, ustekinumab has demonstrated superior efficacy and safety in the treatment of plaque psoriasis by its unique mechanism of inhibiting IL-12/23 inflammatory pathways.7 IL-23 stimulates survival and proliferation of Th17 cells, a key cell that regulates the production of other inflammatory cytokines (IL-17, IL-22, IL-21, IL-6, tumor necrosis factor (TNF)-?)
Gene_expression (production) of IL-21 in Th17 cells associated with psoriasis, necrosis, inflammation, cancer and cytokine
20) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.04 Pain Relevance 0.62

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox