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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.81
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp14, Mmp9) extracellular space (Timp2, Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) nucleus (Timp2) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
cartilage 2
Timp2 (Mus musculus)
Mmp14 (Mus musculus)
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 25 100.00 Very High Very High Very High
rheumatoid arthritis 52 87.12 High High
cINOD 1 44.16 Quite Low
Inflammation 24 39.68 Quite Low
COX-2 inhibitor 2 30.08 Quite Low
diclofenac 1 21.76 Low Low
cytokine 29 8.28 Low Low
chemokine 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 52 87.12 High High
Severe Combined Immunodeficiency 8 74.64 Quite High
Malignant Neoplastic Disease 1 71.76 Quite High
Disease 11 70.96 Quite High
Metastasis 2 69.44 Quite High
Cancer 7 63.68 Quite High
INFLAMMATION 25 43.92 Quite Low
Apoptosis 28 30.80 Quite Low
Adhesions 7 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proteolytic activity at sites of synovial attachment to cartilage was found to be mediated by a complex consisting of MT1-MMP, tissue inhibitor of matrix metalloproteinase (TIMP)-2 and MMP-2, whereby TIMP-2 promotes the binding of pro-MMP-2 to MT1-MMP, by which it is subsequently activated [16].
TIMP-2 Positive_regulation (promotes) of MT1-MMP Binding (binding) of pro-MMP-2 in cartilage associated with metalloproteinase
1) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.81 Pain Relevance 0.65

General Comments

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