INT225221

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Latest revision as of 14:07, 23 September 2012

Context Info
Confidence 0.57
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 18.06
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Nf2) nucleolus (Nf2) plasma membrane (Nf2)
cytoskeleton (Nf2) nucleus (Nf2) protein complex (Nf2)
Anatomy Link Frequency
cerebrospinal fluid 1
plaque 1
Nf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 28 90.44 High High
imagery 434 88.80 High High
Spinal cord 56 88.64 High High
fifth nerve 28 63.92 Quite High
trigeminal ganglion 28 57.60 Quite High
Inflammation 14 47.48 Quite Low
cva 14 46.60 Quite Low
anesthesia 14 5.00 Very Low Very Low Very Low
isoflurane 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurofibromatosis 2 126 100.00 Very High Very High Very High
Meningioma 1274 99.96 Very High Very High Very High
Cancer 532 99.92 Very High Very High Very High
Targeted Disruption 42 99.02 Very High Very High Very High
Malignant Neoplastic Disease 28 96.32 Very High Very High Very High
Hyperostosis 28 94.52 High High
Apoptosis 14 93.88 High High
Carcinoma 14 90.84 High High
Central Nervous System Cancer 28 90.72 High High
Liver Cancer 28 88.80 High High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that biallelic loss of Nf2 is rate-limiting for meningioma development with mice developing a range of meningioma subtypes histologically similar to WHO grade I human meningiomas.
Negative_regulation (loss) of Nf2 associated with meningioma
1) Confidence 0.57 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.44 Pain Relevance 0.03
Overall, our data strongly support the view that one role of loss of p16Ink4 in meningiomagenesis could be to sensitize arachnoid cells to Nf2 loss.
Negative_regulation (loss) of Nf2
2) Confidence 0.50 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 0.94 Pain Relevance 0
Previously, we inactivated Nf2 in homozygous conditional knockout mice by adenoviral Cre (adCre) delivery into arachnoid cells through the cerebrospinal fluid (CSF) of newborn mice (6).
Negative_regulation (inactivated) of Nf2 in cerebrospinal fluid associated with targeted disruption
3) Confidence 0.42 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.28 Pain Relevance 0.04
Previously, we inactivated Nf2 in homozygous conditional knockout mice by adenoviral Cre delivery and showed that Nf2 loss in arachnoid cells is rate-limiting for meningioma formation.
Negative_regulation (loss) of Nf2 associated with targeted disruption and meningioma
4) Confidence 0.42 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Abstract Doc Link PMC2253711 Disease Relevance 1.52 Pain Relevance 0.11
Development of a preclinical model for NF2-related meningiomas: murine meningiomas show radiological features of human meningiomas
Negative_regulation (model) of NF2-related associated with neurofibromatosis 2 and meningioma
5) Confidence 0.41 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.54 Pain Relevance 0.11
Here we have shown that Ink4a nullizygosity enhances the incidence of meningioma formation induced by somatic Nf2 loss in arachnoid cells, and that in mice p16ink4a loss is not a critical event associated with malignant progression of meningioma.
Negative_regulation (loss) of Nf2 associated with malignant neoplastic disease and meningioma
6) Confidence 0.37 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.30 Pain Relevance 0.21
Biallelic inactivation of the neurofibromatosis 2 (NF2) tumor suppressor is associated with meningioma formation in all NF2 patients and 60% of sporadic meningiomas.
Negative_regulation (inactivation) of neurofibromatosis 2 associated with neurofibromatosis 2, meningioma and cancer
7) Confidence 0.37 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Abstract Doc Link PMC2253711 Disease Relevance 1.45 Pain Relevance 0.05
We have previously confirmed that in mice (6), as in humans (3) p53 inactivation does not synergize with Nf2 loss in meningioma initiation and progression.
Negative_regulation (loss) of Nf2 associated with meningioma
8) Confidence 0.37 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 0.95 Pain Relevance 0
One of the genetic mechanisms underlying meningioma tumorigenesis includes early inactivation of the neurofibromatosis 2 (NF2) tumor suppressor gene (12, 18).
Negative_regulation (inactivation) of neurofibromatosis 2 associated with neurofibromatosis 2, meningioma and cancer
9) Confidence 0.37 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.16 Pain Relevance 0.04
One of the genetic mechanisms underlying meningioma tumorigenesis includes early inactivation of the neurofibromatosis 2 (NF2) tumor suppressor gene (12, 18).
Negative_regulation (inactivation) of NF2 associated with neurofibromatosis 2, meningioma and cancer
10) Confidence 0.37 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.17 Pain Relevance 0.04
Biallelic inactivation of the neurofibromatosis 2 (NF2) tumor suppressor is associated with meningioma formation in all NF2 patients and 60% of sporadic meningiomas.
Negative_regulation (inactivation) of NF2 associated with neurofibromatosis 2, meningioma and cancer
11) Confidence 0.37 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Abstract Doc Link PMC2253711 Disease Relevance 1.45 Pain Relevance 0.05
The higher frequency of en plaque meningiomas in our mouse model is likely caused by the multifocality of Nf2 inactivation induced by diffusion in the subarachnoid space of the highly concentrated adCre vector suspension.
Negative_regulation (inactivation) of Nf2 in plaque associated with meningioma
12) Confidence 0.37 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.07 Pain Relevance 0.04
Altogether, these data indicate that in the mouse homozygous inactivation of p16ink4 tumor suppressor gene, with retained p19Arf function, synergizes with Nf2 loss in meningioma initiation, but not in meningioma progression.


Neg (not) Negative_regulation (loss) of Nf2 associated with meningioma and cancer
13) Confidence 0.36 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.56 Pain Relevance 0.08
In the present study, we evaluated the effects in meningioma initiation and progression of p16Ink4a loss with retention of p19Arf in synergy with Nf2 loss.
Negative_regulation (loss) of Nf2 associated with meningioma
14) Confidence 0.36 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.24 Pain Relevance 0.03

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