INT225229

Context Info Confidence 0.19 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.25 Pain Relevance 0

cytoplasm (Cdk6, Cdkn2a) nucleus (Cdk6, Cdkn2a) cell cycle (Cdk6, Cdkn2a) nucleoplasm (Cdkn2a) cell differentiation (Cdk6) aging (Cdkn2a)

Cdk6 (Mus musculus) Cdkn2a (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 2 27.32 imagery 31 24.64 Spinal cord 4 5.00 trigeminal ganglion 2 5.00 fifth nerve 2 5.00 anesthesia 1 5.00 Inflammation 1 5.00 isoflurane 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Retinoblastoma 1 97.36 Cancer 38 96.12 Apoptosis 1 89.48 Meningioma 91 86.12 Monosomy 1 78.92 Chromosome Aberrations 1 74.72 Recurrence 1 70.20 Targeted Disruption 3 52.60 Neurofibromatosis 2 9 48.64 Brain Tumor 1 41.12

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The p16INK4a/p14ARF locus encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in the mouse) by alternative first-exon usage and alternative reading frames (20). p16INK4a arrests cells in the G1 phase of the cell cycle by binding the cyclin-dependant kinases CDK4 and CDK6 and inhibiting their ability to phosphorylate and inactivate the retinoblastoma (RB1) family of tumor suppressor proteins (22). p14ARF acts through MDM2 to stabilize and activate the key checkpoint protein p53, which can arrest cells in both G1 and G2 or induce apoptosis (20).

CDK6 Binding (binding) of p16INK4a associated with cancer, apoptosis and retinoblastoma

1) Confidence 0.19 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.25 Pain Relevance 0

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