INT22546

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2011
Negated 3
Speculated 3
Reported most in Abstract
Documents 97
Total Number 103
Disease Relevance 47.89
Pain Relevance 51.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
cerebral cortex 6
ventral 6
medial 4
leukocytes 4
poly 4
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1622 100.00 Very High Very High Very High
Morphine 279 100.00 Very High Very High Very High
nMDA receptor antagonist 18 100.00 Very High Very High Very High
cocaine 13 100.00 Very High Very High Very High
ischemia 280 99.98 Very High Very High Very High
Clonidine 8 99.98 Very High Very High Very High
bDMF 6 99.98 Very High Very High Very High
cerebral cortex 51 99.84 Very High Very High Very High
lidocaine 31 99.84 Very High Very High Very High
Enkephalin 16 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1693 100.00 Very High Very High Very High
Sepsis 25 100.00 Very High Very High Very High
Adhesions 24 100.00 Very High Very High Very High
Cv Unclassified Under Development 155 99.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 39 99.96 Very High Very High Very High
Cancer 209 99.80 Very High Very High Very High
Spinal Cord Injury 123 99.76 Very High Very High Very High
Targeted Disruption 22 99.74 Very High Very High Very High
Myocardial Infarction 339 99.56 Very High Very High Very High
Pancreatitis 40 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant increase in c-Fos, caspase-3 and IL-1beta expression in model groups compared to the control groups at 3 mo and 5 mo after operation.
Positive_regulation (increase) of Gene_expression (expression) of caspase-3
1) Confidence 0.70 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17552004 Disease Relevance 0.15 Pain Relevance 0
The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats.
Spec (possible) Positive_regulation (-) of Gene_expression (expression) of CPP associated with kappa opioid receptor and morphine
2) Confidence 0.66 Published 2006 Journal Peptides Section Title Doc Link 17097192 Disease Relevance 0.10 Pain Relevance 1.29
Subchronic exposure to HD resulted in significantly increased expression of both anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bax and Caspase-3 in cerebral cortex and cerebellum, which exhibited a dose-dependent pattern.
Positive_regulation (resulted) of Gene_expression (expression) of Caspase-3 in cerebral cortex associated with apoptosis and cerebral cortex
3) Confidence 0.64 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17492505 Disease Relevance 0.50 Pain Relevance 0.47
Though little change was detected in spinal cord, our results showed that the expression of Bcl-2, Bax and Caspase-3 was markedly enhanced in the sciatic nerves.
Positive_regulation (enhanced) of Gene_expression (expression) of Caspase-3 in sciatic nerves associated with sciatic nerve and spinal cord
4) Confidence 0.64 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17492505 Disease Relevance 0.50 Pain Relevance 0.46
These findings indicate that naloxone blocks the acquisition, but enhances the expression of morphine-induced CPP.
Positive_regulation (enhances) of Gene_expression (expression) of CPP associated with narcan and morphine
5) Confidence 0.61 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2305008 Disease Relevance 0 Pain Relevance 1.46
However, pre-testing injections of diazepam blocked the expression of amphetamine-induced CPP, and co-injections of diazepam blocked the formation of amphetamine CPP.
Positive_regulation (induced) of Gene_expression (expression) of CPP
6) Confidence 0.60 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10958076 Disease Relevance 0 Pain Relevance 0
Treatment of cells for 6 h with 1 to 20 mM glutamate resulted in a 35 to 45% cell death that was associated with a 45 to 65% increase in the expression of caspase-3 protein.
Positive_regulation (increase) of Gene_expression (expression) of caspase-3 associated with glutamate and death
7) Confidence 0.55 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC555946 Disease Relevance 0.89 Pain Relevance 0.35
Marked increased caspase-3 expression was present in supraoptic nuclei of hypophysectomy rats.
Positive_regulation (increased) of Gene_expression (expression) of caspase-3
8) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2442085 Disease Relevance 0.09 Pain Relevance 0
Intra-medial septum injections of L-arginine but not L-NAME or sulpiride, 1-2 min before testing, increased the expression of morphine-induced CPP.
Positive_regulation (increased) of Gene_expression (expression) of CPP in medial associated with morphine
9) Confidence 0.54 Published 2003 Journal Brain Res. Section Abstract Doc Link 12763619 Disease Relevance 0 Pain Relevance 0.78
Clonidine increased the level of apoptotic enzyme caspase-3 mRNA expression, as measured by RT-PCR and enhanced the DNA fragmentation, as determined by gel electrophoresis, in the brainstem of the 21-day-old fetuses and 8-day-old rats.
Positive_regulation (increased) of Gene_expression (expression) of caspase-3 mRNA in brainstem associated with medulla, apoptosis and clonidine
10) Confidence 0.54 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15351510 Disease Relevance 0.16 Pain Relevance 0.88
Methodologically, the repeated-testing-schedule produced stable CPP expression in both groups over 12 subsequent tests.
Positive_regulation (stable) of Gene_expression (expression) of CPP
11) Confidence 0.50 Published 2005 Journal Amino Acids Section Abstract Doc Link 15791393 Disease Relevance 0 Pain Relevance 0.58
Although CPP is expressed as increased time spent in a previously rewarded location, the behavioral strategy underlying this change is unknown.
Positive_regulation (increased) of Gene_expression (expressed) of CPP
12) Confidence 0.47 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17093129 Disease Relevance 0 Pain Relevance 0.14
The expression of morphine-induced CPP was significantly blocked by mirtazapine (10 or 30 mg/kg, i.p.), while chronic treatment with mirtazapine (1 or 10 mg/kg, i.p. once, daily, for six consecutive days) significantly attenuated the acquisition of morphine CPP.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with morphine
13) Confidence 0.46 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18618337 Disease Relevance 0.07 Pain Relevance 1.06
Injection of CGP38345 (10, 19, 25 and 50 microg/rat) into the ventral tegmental area significantly reduced the expression of CPP induced by morphine.
Positive_regulation (induced) of Gene_expression (expression) of CPP in ventral associated with ventral tegmentum and morphine
14) Confidence 0.46 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.53
Bicuculline (10 microg/rat) increased the expression of CPP induced by morphine.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with morphine
15) Confidence 0.46 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.57
Muscimol (25 microg/rat) increased the expression of CPP induced by morphine.
Positive_regulation (increased) of Gene_expression (expression) of CPP associated with morphine
16) Confidence 0.46 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.48
Muscimol (25 microg/rat) increased the expression of CPP induced by morphine.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with morphine
17) Confidence 0.46 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.48
Bicuculline (10 microg/rat) increased the expression of CPP induced by morphine.
Positive_regulation (increased) of Gene_expression (expression) of CPP associated with morphine
18) Confidence 0.46 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16253224 Disease Relevance 0 Pain Relevance 1.57
The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats.
Positive_regulation (induced) of Gene_expression (expression) of CPP associated with kappa opioid receptor and morphine
19) Confidence 0.44 Published 2006 Journal Peptides Section Title Doc Link 17097192 Disease Relevance 0.10 Pain Relevance 1.29
Active caspase-3 and Bax expressions were increased, whereas antiapoptotic Bcl-xl and heat shock protein (HSP) 27 expressions in DRGs were increased.
Positive_regulation (increased) of Gene_expression (expressions) of caspase-3 associated with shock
20) Confidence 0.43 Published 2005 Journal Diabetes Section Abstract Doc Link 16249457 Disease Relevance 1.39 Pain Relevance 0.61

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