INT225552

Context Info Confidence 0.09 First Reported 2008 Last Reported 2008 Negated 2 Speculated 0 Reported most in Body Documents 1 Total Number 8 Disease Relevance 1.04 Pain Relevance 0

nucleus (Ncoa6) enzyme binding (Ncoa6) protein complex (Ncoa6)

nr (Mus musculus) Ncoa6 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 16 5.00 cytokine 8 5.00 Inflammation 8 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 192 91.20 Embryonic Lethality 16 85.72 Wound Healing 120 83.00 Apoptosis 144 82.40 Repression 32 70.64 Cataract 8 59.68 Microphthalmia 8 58.12 Congenital Anomalies 8 52.32 Breast Cancer 64 5.00 Cancer 56 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

(L398R), or deletion of helix 12, abolish the association of the NR with NCoA6(NRC) in vitro and in vivo [Mahajan and Samuels, 2000].

NR Binding (association) of NRC

1) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

(L398R), or deletion of helix 12, abolish the association of the NR with NCoA6(NRC) in vitro and in vivo [Mahajan and Samuels, 2000].

NR Binding (association) of NCoA6

2) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

Thus, the phenotypes may result not just from inhibition of NCoA6(ASC-2)-NR interaction, but also from inactivation of a number of receptors that bind DN1 in vivo.

NR Binding (interaction) of NCoA6

3) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.78 Pain Relevance 0

Embedded in this region is the LxxLL-1 motif, which is involved in NR interaction, but not homodimerization of NCoA6(NRC), as suggested by mutational analysis and dimerization data.

NR Neg (not) Binding (interaction) of NCoA6

4) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

NCoA6 may emerge as a specific coactivator for a specific set of NRs due to the fact that NCoA6 displays NR-specific interaction through LxxLL-2.

NR Binding (interaction) of NCoA6

5) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.25 Pain Relevance 0

Embedded in this region is the LxxLL-1 motif, which is involved in NR interaction, but not homodimerization of NCoA6(NRC), as suggested by mutational analysis and dimerization data.

NR Neg (not) Binding (interaction) of NRC

6) Confidence 0.09 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

Thus, yeast two-hybrid assays were used to provide evidence that association with ligand-bound NR leads to a change in NCoA6(NRC) which exposes its activation domains.

NR Binding (bound) of NRC

7) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

Thus, yeast two-hybrid assays were used to provide evidence that association with ligand-bound NR leads to a change in NCoA6(NRC) which exposes its activation domains.

NR Binding (bound) of NCoA6

8) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

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