INT225772

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.60
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
chondrocyte 2
Enpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 99.76 Very High Very High Very High
Inflammation 4 97.28 Very High Very High Very High
Osteoarthritis 30 89.52 High High
depression 4 86.40 High High
spinal inflammation 2 79.36 Quite High
adenocard 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 97.28 Very High Very High Very High
Calcification 92 95.68 Very High Very High Very High
Congenital Anomalies 6 92.80 High High
Aging 26 91.44 High High
Disease 16 90.64 High High
Osteoarthritis 30 89.52 High High
Depression 4 86.40 High High
Low Back Pain 2 79.36 Quite High
Hyperostosis 2 59.28 Quite High
Syndrome 2 37.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It will be of interest to see if the implicated NPP1 sequence variants affect NPP1 expression and function.
Spec (implicated) Regulation (affect) of Gene_expression (expression) of NPP1
1) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.96 Pain Relevance 0.26
Physiologic chondrocyte PPi metabolism is regulated in part by growth factor and cytokine regulatory effects on chondrocyte NPP1 expression.
Regulation (effects) of Gene_expression (expression) of NPP1 in chondrocyte associated with cytokine
2) Confidence 0.27 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.64 Pain Relevance 0.14

General Comments

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