INT2258

From wiki-pain
Revision as of 19:50, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1976
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 5.51
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gip) extracellular region (Gip) cytoplasm (Gip)
Anatomy Link Frequency
plasma 2
fat 2
blood 1
duodenum 1
Gip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 12 99.96 Very High Very High Very High
Enkephalin 20 99.22 Very High Very High Very High
anesthesia 4 99.06 Very High Very High Very High
Chronic pancreatitis 19 97.72 Very High Very High Very High
abdominal pain 1 92.16 High High
narcan 6 85.28 High High
tolerance 2 81.56 Quite High
vagus nerve 1 73.32 Quite High
peptic ulcer disease 1 71.48 Quite High
Endogenous opioid 2 63.12 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 22 97.80 Very High Very High Very High
Pancreatitis 19 97.72 Very High Very High Very High
Celiac Disease 12 95.80 Very High Very High Very High
Disease 13 95.48 Very High Very High Very High
Abdominal Pain 1 92.16 High High
Body Weight 3 91.72 High High
Hypoglycemia 1 90.00 High High
Steatorrhea 3 88.28 High High
Impaired Glucose Tolerance 4 83.52 Quite High
Obesity 3 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Luminal perfusion of the rat jejunum for 4 h, under pentobarbital sodium anesthesia, with 100 mM D-glucose produced a significant increase in plasma GIP levels.
Positive_regulation (increase) of GIP in plasma associated with anesthesia
1) Confidence 0.60 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8843773 Disease Relevance 0 Pain Relevance 0.10
In chronic pancreatitis endocrine insufficiency may induce an exaggerated GIP response and severe exocrine insufficiency may prevent fat induced GIP release.
Positive_regulation (induced) of GIP in fat associated with chronic pancreatitis
2) Confidence 0.48 Published 1976 Journal Diabetologia Section Abstract Doc Link 1001849 Disease Relevance 0.33 Pain Relevance 0.34
Both methionine- and leucine-enkephalins caused a dose-dependent inhibition of gastric inhibitory polypeptide (GIP) stimulated SLI secretion.
Positive_regulation (stimulated) of GIP associated with somatostatin and enkephalin
3) Confidence 0.44 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6137272 Disease Relevance 0 Pain Relevance 1.07
Both methionine- and leucine-enkephalins caused a dose-dependent inhibition of gastric inhibitory polypeptide (GIP) stimulated SLI secretion.
Positive_regulation (stimulated) of gastric inhibitory polypeptide associated with somatostatin and enkephalin
4) Confidence 0.44 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6137272 Disease Relevance 0 Pain Relevance 1.07
The present study was designed to determine the effects of intravenously administered galanin or gastrin-releasing peptide (GRP) on glucose- and/or glucose-dependent insulinotropic peptide (GIP)-stimulated insulin release in the anaesthetized rat.
Positive_regulation (-stimulated) of insulinotropic
5) Confidence 0.39 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2445005 Disease Relevance 0 Pain Relevance 0
The present study was designed to determine the effects of intravenously administered galanin or gastrin-releasing peptide (GRP) on glucose- and/or glucose-dependent insulinotropic peptide (GIP)-stimulated insulin release in the anaesthetized rat.
Positive_regulation (-stimulated) of GIP
6) Confidence 0.39 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2445005 Disease Relevance 0 Pain Relevance 0
The response of serum immunoreactive gastric inhibitory polypeptide (IR-GIP), gastrin (IRG) and insulin (IRI) to a mixed standard meal was measured in 15 controls, 6 patients with coeliac disease, 26 patients with chronic pancreatitis and partial duodenopancreatectomy (Whipple's procedure).
Positive_regulation (response) of gastric inhibitory polypeptide associated with celiac disease, disease and chronic pancreatitis
7) Confidence 0.39 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.69 Pain Relevance 0.09
The response of serum immunoreactive gastric inhibitory polypeptide (IR-GIP), gastrin (IRG) and insulin (IRI) to a mixed standard meal was measured in 15 controls, 6 patients with coeliac disease, 26 patients with chronic pancreatitis and partial duodenopancreatectomy (Whipple's procedure).
Positive_regulation (response) of GIP associated with celiac disease, disease and chronic pancreatitis
8) Confidence 0.39 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.70 Pain Relevance 0.09
This demonstrates that the duodenum is not necessary for GIP release and that pancreatic and jejunal gastrin are without clinical significance.
Neg (not) Positive_regulation (necessary) of GIP in duodenum
9) Confidence 0.39 Published 1976 Journal Diabetologia Section Abstract Doc Link 955338 Disease Relevance 0.74 Pain Relevance 0.16
After restoration of the GIP response to fat by pancreatin, the inhibitory effect of IV glucose on fat-induced GIP increase was restored.
Positive_regulation (increase) of GIP in fat
10) Confidence 0.37 Published 1980 Journal Diabetologia Section Abstract Doc Link 6997121 Disease Relevance 0.52 Pain Relevance 0.23
Postprandial GIP release and serum insulin levels are not affected by vagotomy, but basal GIP levels are increased after vagotomy.
Positive_regulation (increased) of GIP
11) Confidence 0.31 Published 1979 Journal World J Surg Section Abstract Doc Link 390900 Disease Relevance 0.14 Pain Relevance 0.11
Higher values of GIP were demonstrated at 60 and 120 min in patients without diabetes than in patients with it.
Positive_regulation (values) of GIP
12) Confidence 0.27 Published 1996 Journal Regul. Pept. Section Body Doc Link 8988521 Disease Relevance 0.16 Pain Relevance 0
The attenuation of complaints cannot be explained by a decreasing sucrase inhibition, since the increase of glucose, IRI, and IR-GIP after sucrose loading at the beginning and after 4 and 8 weeks was equally impaired by acarbose.
Positive_regulation (increase) of IR-GIP
13) Confidence 0.15 Published 1981 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7034156 Disease Relevance 0.09 Pain Relevance 0.09
In contrast, the late-phase (20-120 min) plasma insulin response to GIP was attenuated, compared with the plasma insulin response to GLP-1, in all five groups.
Positive_regulation (response) of GIP in plasma
14) Confidence 0.07 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 14557471 Disease Relevance 1.13 Pain Relevance 0.07
Thus, DMG indeed appears as a suitable tool to potentiate the insulinotropic action of GLP-1.
Positive_regulation (potentiate) of insulinotropic
15) Confidence 0.04 Published 2001 Journal Int. J. Mol. Med. Section Abstract Doc Link 11605022 Disease Relevance 0.08 Pain Relevance 0
Glucagon-like peptide 1(7-36)amide (GLP-1), an intestinally derived insulinotropic hormone, represents a potential therapeutic agent for type 2 diabetes, because exogenous GLP-1 has been shown to increase the insulin and reduce the glucagon concentrations in these patients, and thus induce lower blood glucose, but without causing hypoglycemia.
Positive_regulation (derived) of insulinotropic in blood associated with hypoglycemia and diabetes mellitus
16) Confidence 0.00 Published 2000 Journal Pancreas Section Abstract Doc Link 10630380 Disease Relevance 0.92 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox