INT225802

Context Info Confidence 0.04 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.00 Pain Relevance 0.03

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)

Anatomy Link Frequency osteoblasts 1 Enpp1 (Mus musculus) Ppi-rs (Mus musculus)

Pain Link Frequency Relevance Heat Osteoarthritis 30 64.44 cytokine 6 5.00 depression 4 5.00 Inflammation 4 5.00 adenocard 4 5.00 spinal inflammation 2 5.00

Disease Link Frequency Relevance Heat Calcification 92 100.00 Metastasis 2 91.12 Obesity 2 88.96 Adhesions 2 87.72 Insulin Resistance 2 80.20 Diabetes Mellitus 4 72.56 Osteoporosis 8 69.20 Osteoarthritis 30 64.44 Disease 16 48.52 Cleidocranial Dysplasia 2 48.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Last, NPP1 not only generates PPi but also modulates N-glycosylation and secretion of glycoproteins, and proteoglycans sulfation [6–8], and NPP1 also scavenges ATP and thereby regulates purinergic receptor signaling.

NPP1 Binding (generates) of PPi

1) Confidence 0.04 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.50 Pain Relevance 0.03

This review focuses on the functions of NPP1 in the regulation of physiologic and pathologic calcification, principally via PPi generation from nucleoside triphosphates in tissues (and cells) including cartilage (and chondrocytes), bone (and osteoblasts), and large arteries (and smooth muscle cells (SMCs)).

NPP1 Binding (generation) of PPi in osteoblasts associated with calcification

2) Confidence 0.04 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.50 Pain Relevance 0

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