INT22591

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Context Info
Confidence 0.51
First Reported 1984
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 5.04
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hmbs) cytoplasm (Hmbs)
Anatomy Link Frequency
liver 3
sciatic nerve 1
Hmbs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 9 99.52 Very High Very High Very High
Sciatic nerve 4 99.12 Very High Very High Very High
anesthesia 4 97.20 Very High Very High Very High
antagonist 1 96.48 Very High Very High Very High
Serotonin 2 95.72 Very High Very High Very High
Dismenorea 4 94.20 High High
peripheral neuropathy 8 92.40 High High
Peripheral nervous system 4 86.44 High High
Disease Link Frequency Relevance Heat
Porphyria 24 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 8 100.00 Very High Very High Very High
Acute Intermittent Porphyria 12 99.84 Very High Very High Very High
Disease 2 99.64 Very High Very High Very High
Variegate Porphyria 4 95.92 Very High Very High Very High
Congenital Anomalies 8 95.52 Very High Very High Very High
Dysmenorrhea 4 94.20 High High
Peripheral Neuropathy 8 92.40 High High
Neuropathic Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It may well be that a reduced activity of PBGD in other tissues than the liver is of importance too.
Negative_regulation (reduced) of PBGD in liver
1) Confidence 0.51 Published 2000 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11202056 Disease Relevance 0.35 Pain Relevance 0.09
Acute intermittent porphyria (AIP) is an inherited disease resulting from a reduced activity of PBGD.
Negative_regulation (reduced) of PBGD associated with porphyria and disease
2) Confidence 0.51 Published 2000 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11202056 Disease Relevance 0.39 Pain Relevance 0.10
MDL 72222 inhibited BP and RNA responses to PBG to a similar extent in conscious and anesthetized SAD rats.
Negative_regulation (inhibited) of PBG associated with porphyria and pressure volume 2 under development
3) Confidence 0.36 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2309912 Disease Relevance 1.58 Pain Relevance 0.65
An autopsy case of acute porphyria with a decrease of both uroporphyrinogen I synthetase and ferrochelatase activities.
Negative_regulation (decrease) of uroporphyrinogen I synthetase associated with acute intermittent porphyria
4) Confidence 0.12 Published 1984 Journal Acta Neuropathol. Section Title Doc Link 6089495 Disease Relevance 0.64 Pain Relevance 0.25
In the analysis of the enzymatic activities of the liver and bone narrow, the activity of ALA synthetase (ALA-S) was markedly increased, and the activities of both uroporphyrinogen I synthetase (URO-S) and ferrochelatase were decreased.
Negative_regulation (decreased) of uroporphyrinogen I synthetase in liver
5) Confidence 0.12 Published 1984 Journal Acta Neuropathol. Section Abstract Doc Link 6089495 Disease Relevance 0.70 Pain Relevance 0.23
Biochemical analysis of the sciatic nerve showed an increase of ALA-S activity and a decrease of both URO-S and ALA dehydrase activities.
Negative_regulation (decrease) of URO-S in sciatic nerve associated with sciatic nerve
6) Confidence 0.12 Published 1984 Journal Acta Neuropathol. Section Abstract Doc Link 6089495 Disease Relevance 0.68 Pain Relevance 0.20
In the analysis of the enzymatic activities of the liver and bone narrow, the activity of ALA synthetase (ALA-S) was markedly increased, and the activities of both uroporphyrinogen I synthetase (URO-S) and ferrochelatase were decreased.
Negative_regulation (decreased) of URO-S in liver
7) Confidence 0.08 Published 1984 Journal Acta Neuropathol. Section Abstract Doc Link 6089495 Disease Relevance 0.70 Pain Relevance 0.23

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