INT225959

From wiki-pain
Revision as of 18:53, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.01
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
basal cell 2
hair follicle 1
epithelial cells 1
keratinocytes 1
KRT15 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 42.00 Quite Low
Potency 3 5.68 Low Low
medulla 21 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
cryotherapy 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 338 99.32 Very High Very High Very High
Basal Cell Carcinoma 9 97.72 Very High Very High Very High
Targeted Disruption 61 93.88 High High
Breast Cancer 36 75.52 Quite High
Disease Progression 6 74.72 Quite High
Adenocarcinoma 139 73.48 Quite High
Metaplasia 12 61.52 Quite High
Cervical Intraepithelial Neoplasia 3 56.88 Quite High
Cleidocranial Dysplasia 12 55.48 Quite High
Squamous Cell Carcinoma 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies indicate that the three cultures express markers of stratified epithelia such as cytokeratin K3, K4, K13, K15, and connexin 43.
Gene_expression (express) of K15
1) Confidence 0.48 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.07 Pain Relevance 0
K15 expression in basal cells is downregulated in activated epidermal keratinocytes such as in organotypic cultures and in hyperproliferation (Waseem et al. 1999) or upon wounding (Porter et al. 2000).
Gene_expression (expression) of K15 in keratinocytes
2) Confidence 0.42 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.36 Pain Relevance 0
RT–PCR analysis showed that cultured oral epithelial cells expressed markers of epithelial differentiation such as cytokeratin K3, K4, K13, K15 and connexin 43.
Gene_expression (expressed) of K15 in epithelial cells
3) Confidence 0.37 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
Cytokeratin K15, expressed in basal and suprabasal cells of the limbus [25], was also observed in all three cultured cells.
Gene_expression (expressed) of Cytokeratin K15
4) Confidence 0.37 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
As to the occurrence of K15 in tumors, the literature is inconclusive as to whether there is differential expression of K15 among cutaneous tumors (benign follicular tumors versus basal cell carcinomas), possibly due to the use of different antibodies1 (see also above), and thus a putative diagnostic application of K15 immunohistochemistry in dermatopathology is still open (Kanitakis et al. 1999; Jih et al. 1999; Porter et al. 2000; Kurzen et al. 2001).
Gene_expression (expression) of K15 in basal cell associated with cancer and basal cell carcinoma
5) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.49 Pain Relevance 0
Some, but not all, of the cells present within hair follicle bulge were also found to co-express CTIP2, keratin K15, but not CD34, indicating that a subset of K15+ CD34?
Gene_expression (keratin) of K15 in hair follicle
6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.48 Pain Relevance 0
This involves a switch from expression of the basal cell keratins (K5, K14, K15) to the suprabasal epidermal keratins, the type II keratin K1 and subsequently the type I keratin K10 (Fig. 4b; Fuchs and Green 1980; Moll et al. 1982b; Tseng et al. 1982, Weiss et al. 1984; Roop 1987, Stoler et al. 1988).
Gene_expression (expression) of K15 in basal cell
7) Confidence 0.33 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.62 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox