INT226184

Context Info Confidence 0.87 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.52 Pain Relevance 0.38

endosome (Cftr) transport (Cftr) ATPase activity (Cftr) enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr)

Cftr (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 74 98.60 sodium channel 3 84.36 Inflammation 65 82.08 aspirin 10 48.00 imagery 10 25.00 cytokine 18 5.00 Inflammatory response 12 5.00 alcohol 10 5.00 anesthesia 7 5.00 Bioavailability 4 5.00

Disease Link Frequency Relevance Heat Disease 25 98.88 Cystic Fibrosis 74 98.60 Hypersensitivity 4 88.04 INFLAMMATION 71 82.08 Apoptosis 4 77.16 Cancer 9 67.00 Respiratory Sounds 1 65.20 Solid Tumor 2 64.72 Airway Obstruction 3 64.68 Pneumonia 9 63.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The absence of CFTR or its F508del mutation (known to promote CFTR degradation) may increase cPLA2?

Protein_catabolism (degradation) of CFTR

1) Confidence 0.87 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.46 Pain Relevance 0.12

F508-CFTR is misfolded, ubiquitinated, and prematurely degraded by proteasome mediated- degradation.

Protein_catabolism (degraded) of CFTR

2) Confidence 0.86 Published 2010 Journal J Nanobiotechnology Section Abstract Doc Link PMC2954907 Disease Relevance 0.26 Pain Relevance 0.13

This ability to ameliorate other primary aspects of CF disease pathophysiology in addition to the rescue of misfolded CFTR from proteasomal degradation is promising for CF therapeutics.

Protein_catabolism (degradation) of CFTR associated with disease

3) Confidence 0.76 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.43 Pain Relevance 0.08

For example, in cystic fibrosis, the mutant form of the transmembrane conductance regulator protein (CFTR) is selectively degraded before it reaches the cell surface [23].

Protein_catabolism (degraded) of CFTR associated with fibrosis and cystic fibrosis

4) Confidence 0.22 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.38 Pain Relevance 0.05

General Comments

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