INT22630

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Context Info
Confidence 0.48
First Reported 1990
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.27
Pain Relevance 5.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 39 100.00 Very High Very High Very High
Cholecystokinin 36 100.00 Very High Very High Very High
opiate 19 100.00 Very High Very High Very High
Central grey 16 100.00 Very High Very High Very High
GABAergic 1 100.00 Very High Very High Very High
Opioid 9 99.44 Very High Very High Very High
tolerance 18 99.16 Very High Very High Very High
antagonist 20 98.84 Very High Very High Very High
Potency 2 98.46 Very High Very High Very High
addiction 5 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 19 100.00 Very High Very High Very High
Panic Disorder 12 99.52 Very High Very High Very High
Anxiety Disorder 46 98.72 Very High Very High Very High
Schizophrenia 4 98.36 Very High Very High Very High
Movement Disorders 1 97.76 Very High Very High Very High
Nociception 1 96.48 Very High Very High Very High
Appetite Loss 1 95.96 Very High Very High Very High
Opiate Addiction 2 82.68 Quite High
Pain 27 78.96 Quite High
Sleep Disorders 12 64.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This emphasizes the central importance of PAG in the MOR/CCK interactions that lead to opioid tolerance.
Positive_regulation (importance) of CCK Binding (interactions) of associated with tolerance, opioid, cholecystokinin, central grey and morphine
1) Confidence 0.48 Published 2003 Journal Pain Section Abstract Doc Link 12620592 Disease Relevance 0.71 Pain Relevance 2.40
Specific CCK8S binding was significantly increased in the supraoptic nuclei of both morphine-dependent and salt-loaded (2% sodium chloride to drink for 48 h) rats compared to their respective controls (P < 0.05).
Positive_regulation (increased) of CCK8S Binding (binding) of associated with morphine
2) Confidence 0.47 Published 1998 Journal Brain Res. Section Abstract Doc Link 9507122 Disease Relevance 0 Pain Relevance 0.92
This rank order correlates well with the potency of the antagonists in blocking CCK-B receptors in rodents and suggests that CCK/opiate interactions in this species are mediated by CCK-B receptors.
Positive_regulation (mediated) of CCK Binding (interactions) of associated with antagonist, opiate and potency
3) Confidence 0.45 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2311658 Disease Relevance 0.21 Pain Relevance 2.01
The interaction of CCK with GABAergic inhibitory neurotransmission, mediated probably through CCK-B receptors, could be the neurochemical substrate for anxious type of exploratory behavior.
Positive_regulation (mediated) of CCK Binding (interaction) of associated with gabaergic and cholecystokinin
4) Confidence 0.33 Published 1999 Journal Crit Care Section Body Doc Link PMC137231 Disease Relevance 1.34 Pain Relevance 0.58

General Comments

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