INT226340

Context Info Confidence 0.03 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 3.84 Pain Relevance 0.85

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4) enzyme binding (CD4)

Anatomy Link Frequency T-cell 4 CD4 (Homo sapiens) IFNA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory response 14 99.92 cytokine 188 98.60 agonist 40 87.00 Inflammation 194 82.88 chemokine 46 76.92 psoriasis 2 71.76 Crohn's disease 2 71.20 antagonist 68 65.28 fibrosis 4 32.88 methotrexate 8 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 210 99.52 Infection 32 98.16 Asthma 630 95.32 Cancer 10 92.08 Necrosis 4 91.60 Thrombocytopenia 2 77.76 Anaemia 2 76.92 Psoriasis 2 71.76 Disease 40 71.20 Recurrence 12 59.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to priming CD4+ T cells for high IFN-?

CD4 Binding (priming) of IFN in T cells

1) Confidence 0.03 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.11 Pain Relevance 0.22

In fact S1P decreases CD4 T cell generation of IFN-?

CD4 Binding (generation) of IFN in T cell

2) Confidence 0.03 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.66 Pain Relevance 0.37

CD4 T-cell responses are associated with the interferon (IFN)-?

CD4 Binding (associated) of interferon in T-cell

3) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 1.04 Pain Relevance 0.13

CD4 T-cell responses are associated with the interferon (IFN)-?

CD4 Binding (associated) of IFN in T-cell

4) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 1.04 Pain Relevance 0.13

General Comments

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