INT226364

Context Info Confidence 0.11 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.41 Pain Relevance 0.17

signal transduction (IL19, TNF) extracellular space (IL19, TNF) extracellular region (IL19, TNF) plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)

Anatomy Link Frequency monocytes 2 IL19 (Homo sapiens) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 91 90.56 adenocard 2 82.88 Inflammation 96 5.00 antagonist 34 5.00 chemokine 23 5.00 agonist 20 5.00 Inflammatory response 6 5.00 methotrexate 4 5.00 Inflammatory mediators 2 5.00 withdrawal 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 9 95.12 Asthma 315 70.96 Skin Cancer 1 67.80 INFLAMMATION 103 5.00 Targeted Disruption 20 5.00 Eosinophilia 19 5.00 Disease 17 5.00 Occupational Lung Diseases 15 5.00 Rhinitis 11 5.00 Hypersensitivity 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The IL-19 gene is up-regulated in monocytes by LPS and GM-CSF [258] and, in turn, IL-19 induces the production of IL-6, TNF-?

IL-19 Positive_regulation (induces) of Gene_expression (production) of TNF in monocytes

1) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.41 Pain Relevance 0.17

General Comments

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