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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.79
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
Th1 cells 2
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 35 100.00 Very High Very High Very High
Inflammation 160 83.44 Quite High
cytokine 164 78.76 Quite High
antagonist 60 77.72 Quite High
rheumatoid arthritis 14 77.44 Quite High
tolerance 12 70.80 Quite High
psoriasis 4 51.04 Quite High
cINOD 5 22.88 Low Low
Arthritis 3 5.76 Low Low
agonist 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 119 98.48 Very High Very High Very High
Pulmonary Disease 109 98.40 Very High Very High Very High
Renal Disease 31 98.12 Very High Very High Very High
Asthma 326 88.88 High High
Immune System Diseases 2 86.32 High High
Pneumonia 13 83.84 Quite High
Necrosis 5 83.52 Quite High
Cancer 9 83.44 Quite High
INFLAMMATION 167 79.76 Quite High
Rheumatoid Arthritis 14 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They showed that deficiency of the chemokine receptor CXCR3-bering T cells (highly expressed on Th1 cells) leads to significant morphological and functional improvement of nephritic kidneys.
Negative_regulation (deficiency) of CXCR3 in Th1 cells associated with chemokine
1) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 1.31 Pain Relevance 0.31
CXCL10 replacement partially restored Th1 cell trafficking in STAT1-deficient mice in vivo, and deficiency in CXCR3, the receptor for CXCL9, CXCL10, and CXCL11, impaired the trafficking of Th1 cells [116].
Negative_regulation (deficiency) of CXCR3 in Th1 cells
2) Confidence 0.17 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.45 Pain Relevance 0.11
Specific inhibitors of CXCL10/CXCR3 interaction might therefore be useful for COPD treatment.
Negative_regulation (inhibitors) of CXCR3 associated with pulmonary disease
3) Confidence 0.12 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.04 Pain Relevance 0.35

General Comments

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