INT226453

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 12.66
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (IL15) aging (IL15) Golgi apparatus (IL15)
cell-cell signaling (IL15) cytoplasm (IL15) extracellular space (IL15)
Anatomy Link Frequency
T cells 8
smooth muscle 2
intestinal epithelium 2
gut 2
IL15 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 281 98.40 Very High Very High Very High
cytokine 206 97.88 Very High Very High Very High
Prostatitis 4 91.72 High High
chemokine 46 6.48 Low Low
antagonist 82 5.00 Very Low Very Low Very Low
agonist 48 5.00 Very Low Very Low Very Low
cINOD 32 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
cva 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 17 100.00 Very High Very High Very High
Stress 14 100.00 Very High Very High Very High
Asthma 630 99.98 Very High Very High Very High
Hypersensitivity 22 99.00 Very High Very High Very High
INFLAMMATION 305 98.40 Very High Very High Very High
Pulmonary Disease 4 97.40 Very High Very High Very High
Mycobacterial Infection 2 97.00 Very High Very High Very High
Sarcoidosis 2 96.44 Very High Very High Very High
Disease 178 95.16 Very High Very High Very High
Infarction 32 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Positive_regulation (elevated) of Gene_expression (expression) of IL-15 in T cells associated with inflammation, infarction and cytokine
1) Confidence 0.24 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.12 Pain Relevance 0.49
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Positive_regulation (elevated) of Gene_expression (expression) of interleukin 15 in T cells associated with inflammation, infarction and cytokine
2) Confidence 0.24 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.12 Pain Relevance 0.49
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IL15 associated with adhesions
3) Confidence 0.14 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.37 Pain Relevance 0
In an animal model of asthma overexpression of IL-15 suppresses Th2-mediated-allergic airway response via induction of CD8+ T cell-mediated Tc1 response [236].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-15 in T cell associated with asthma and hypersensitivity
4) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.51 Pain Relevance 0.18
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Positive_regulation (elevated) of in smooth muscle Gene_expression (expression) of interleukin 15 in T cells associated with inflammation, infarction and cytokine
5) Confidence 0.08 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.12 Pain Relevance 0.49
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Positive_regulation (elevated) of in smooth muscle Gene_expression (expression) of IL-15 in T cells associated with inflammation, infarction and cytokine
6) Confidence 0.08 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.12 Pain Relevance 0.49
The expression of IL-15 is also increased in the bronchial mucosa of asthmatic patients compared to normal subjects.
Positive_regulation (increased) of Gene_expression (expression) of IL-15 associated with asthma
7) Confidence 0.07 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.60 Pain Relevance 0.21
Thus, innate gluten peptides cause damage to the gut by inducing epithelial stress and IL-15 expression, which in turn lead to IEL infiltration and targeted killing of MIC-expressing enterocytes by NK receptor+ IEL in a manner independent of T cell receptor specificity.
Positive_regulation (inducing) of Gene_expression (expression) of IL-15 in gut associated with stress
8) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.34 Pain Relevance 0.03
The in vivo relevance of these effects is underscored by the presence of upregulated IL-15 [146,150,151], increased MIC expression on enterocytes [145,149], and CD94+ IEL infiltration [147] in the intestinal epithelium of active celiac patients.
Positive_regulation (increased) of Gene_expression (expression) of IL-15 in intestinal epithelium
9) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.38 Pain Relevance 0

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