INT226597

Context Info Confidence 0.08 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0.21

nucleus (DRGX)

Anatomy Link Frequency neurons 2 DRGX (Homo sapiens)

Pain Link Frequency Relevance Heat hyperexcitability 3 100.00 Pain 15 98.96 addiction 7 75.04 Neuronal excitability 1 8.00 Lasting pain 2 5.00 sodium channel 2 5.00 burning pain 2 5.00 tetrodotoxin 1 5.00 Congenital analgesia 1 5.00 Paroxysmal extreme pain disorder 1 5.00

Disease Link Frequency Relevance Heat Erythermalgia 25 98.16 Pain 15 5.00 Nociception 3 5.00 Somatoform Disorder 2 5.00 Congenital Pain Insensitivity 1 5.00 Epilepsy 1 5.00 Non-diabetic Peripheral Neuropathy 1 5.00 Ganglion Cysts 1 5.00 Disease 1 5.00 Febrile Convulsions 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These changes of the biophysical properties of NaV1.7 are expected to contribute to hyperexcitability of DRG neurons, which underlies painful symptoms of erythromelalgia.

Regulation (contribute) of Localization (hyperexcitability) of DRG in neurons associated with pain, erythermalgia and hyperexcitability

1) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2262064 Disease Relevance 0.32 Pain Relevance 0.21

General Comments

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