INT226668

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.77
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
T cells 2
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 20 66.56 Quite High
imagery 10 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Opioid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 375 98.64 Very High Very High Very High
Infection 50 94.00 High High
Apoptosis 20 91.60 High High
Cytomegalovirus Infection 5 87.64 High High
Superinfection 20 50.68 Quite High
Cancer 15 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of Gag-GFP expressing Jurkat cells with SDF-1, PMA and ionomycin revealed that downregulation of endogenous CXCR4 was clearly attenuated by expression of wt Gag-GFP (Fig. 3C,D,E).
Positive_regulation (attenuated) of Negative_regulation (downregulation) of CXCR4
1) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.82 Pain Relevance 0
In order to determine whether SDF-1 induced HA-CXCR4 downregulation is dependent on the ESCRT-I complex, cells were depleted of the critical ESCRT-I component, TSG101.
Spec (whether) Positive_regulation (dependent) of Spec (whether) Negative_regulation (downregulation) of CXCR4
2) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0 Pain Relevance 0
SDF-1 induced CXCR4 downregulation is ESCRT-I dependent
Positive_regulation (induced) of Negative_regulation (downregulation) of CXCR4
3) Confidence 0.27 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.34 Pain Relevance 0
We speculate that during the late stages of the viral life cycle when mostly structural proteins such as Gag are expressed, SDF-1 induced CXCR4 downregulation is attenuated resulting in the accumulation of densensitized CXCR4 within intracellular compartments.
Positive_regulation (induced) of Negative_regulation (downregulation) of CXCR4
4) Confidence 0.27 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.74 Pain Relevance 0.13
In order to examine the effects of Gag expression on endogenous CXCR4, we monitored the kinetics of SDF-1 induced downregulation of CXCR4 in Jurkat T cells.
Positive_regulation (induced) of Negative_regulation (downregulation) of CXCR4 in T cells
5) Confidence 0.27 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.86 Pain Relevance 0

General Comments

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