INT226691

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.90
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
stromal cells 4
CD86 2
immune cells 2
B-cells 2
lung 2
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 62 100.00 Very High Very High Very High
cytokine 28 99.36 Very High Very High Very High
fibrosis 29 83.64 Quite High
Multiple sclerosis 2 80.20 Quite High
Inflammation 62 79.00 Quite High
Central nervous system 2 50.80 Quite High
metalloproteinase 6 33.20 Quite Low
Inflammatory mediators 2 29.72 Quite Low
ischemia 6 24.36 Low Low
imagery 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 300 100.00 Very High Very High Very High
Carcinoma 25 99.66 Very High Very High Very High
Obesity 26 98.48 Very High Very High Very High
Cancer 291 98.08 Very High Very High Very High
Metastasis 237 97.64 Very High Very High Very High
Chronic Lymphoid Leukemia 7 97.00 Very High Very High Very High
Hypoxia 157 94.72 High High
Cytomegalovirus Infection 4 94.56 High High
Superinfection 16 90.36 High High
Apoptosis 85 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Gene_expression (expressed) of Cxcr4
1) Confidence 0.57 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Gene_expression (expressed) of Cxcr4
2) Confidence 0.57 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
We also evaluated CXCR4 expression on B-cells in 54 paired BM-aspirates and PB (10 WM, 14 DLBC, 18 FL and 12 CLL).
Positive_regulation (evaluated) of Gene_expression (expression) of CXCR4 in B-cells associated with chronic lymphoid leukemia
3) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 0.39 Pain Relevance 0
For CXCR4 neutralization, 106 c-Kithigh BMC were pre-incubated with 20 ?
Positive_regulation (incubated) of Gene_expression (neutralization) of CXCR4
4) Confidence 0.41 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.07 Pain Relevance 0
and Smads increases VEGF and CXCR4 expression
Positive_regulation (increases) of Gene_expression (expression) of CXCR4
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.54 Pain Relevance 0
In particular, it has been shown that overexpression of CXCR4 increases migration and proliferation of human adipose tissue-derived stromal cells [40].
Positive_regulation (increases) of Gene_expression (overexpression) of CXCR4 in stromal cells associated with obesity
6) Confidence 0.39 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.27 Pain Relevance 0
In particular, it has been shown that overexpression of CXCR4 increases migration and proliferation of human adipose tissue-derived stromal cells [40].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CXCR4 in stromal cells associated with obesity
7) Confidence 0.39 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.27 Pain Relevance 0
Carcinomas frequently have elevated CXCR4 expression, which is a key regulatory element in enabling tumor cell metastasis, a locomotory event characteristic of migrating immune cells [21].
Positive_regulation (elevated) of Gene_expression (expression) of CXCR4 in immune cells associated with cancer, carcinoma and metastasis
8) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.91 Pain Relevance 0.11
and 1% O2; however, there was no additional increase in CXCR4 mRNA expression with combined treatment.
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of CXCR4 mRNA
9) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.69 Pain Relevance 0
Mobilization and homing of fibrocytes into the lung is facilitated by their expression of chemokine receptors, such as CXCR4, and the enhanced expression in the injured lung of the cognate ligands for these receptors (i.e., stromal cell derived factor1 alpha and CXCL12).
Positive_regulation (facilitated) of Gene_expression (expression) of CXCR4 in lung associated with chemokine
10) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.68 Pain Relevance 0.19
In contrast, others have, in some cases, seen an upregulation in cell surface expression of CXCR4 in HIV-1 infected CD4+ T cells [55].
Positive_regulation (upregulation) of Gene_expression (expression) of CXCR4 in T cells associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 1.06 Pain Relevance 0
Thus, accumulation of intracellular HA-CXCR4 did not result in altered SDF-1 induced CXCR4 signaling in Gag expressing cells.


Positive_regulation (induced) of Gene_expression (signaling) of CXCR4
12) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.46 Pain Relevance 0
SDF-1 induced CXCR4 signaling could potentially be beneficial to viral replication since it results in the activation of transcription factors such as NF?
Positive_regulation (induced) of Gene_expression (signaling) of CXCR4
13) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 1.00 Pain Relevance 0
In the present study we found that 24-hr DINP exposure significantly increased the production of the TH2-attracting chemokines TARC/CCL17 (Figure 3A) and MDC/CCL22 (Figure 3B) but not the TH1-polarizing cytokine IL-12p40 (data not shown), and increased the expression of CCR7, CXCR4 (Figure 3C,D), MHC class II, CD80, and CD86 (Figure 3E,F) in BMDCs.
Positive_regulation (increased) of Gene_expression (expression) of CXCR4 in CD86 associated with chemokine and cytokine
14) Confidence 0.29 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.25 Pain Relevance 0.24
In transfected COS-1 cells, both HA-CXCR4 and HIV-1 Gag were exogenously expressed at high levels.
Positive_regulation (levels) of Gene_expression (expressed) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
15) Confidence 0.27 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.69 Pain Relevance 0

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