INT226837

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 3.59
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pax7) DNA binding (Pax7)
Anatomy Link Frequency
muscle 4
tibialis anterior 2
satellite cells 2
Pax7 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 54 76.24 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 120 99.50 Very High Very High Very High
Appetite Loss 126 96.16 Very High Very High Very High
Cancer 258 95.80 Very High Very High Very High
Injury 12 92.68 High High
Chronic Renal Failure 6 90.20 High High
Body Weight 37 88.76 High High
Muscular Atrophy 78 87.92 High High
Hepatocellular Cancer 18 86.24 High High
Aging 24 86.08 High High
Colon Cancer 6 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In C26 hosts, muscle wasting is also associated with increased Pax7 expression and reduced myogenin levels.
Positive_regulation (increased) of Gene_expression (expression) of Pax7 in muscle associated with frailty
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965098 Disease Relevance 0.80 Pain Relevance 0.04
In previous reports Pax7 overexpression was found to result in inhibition of myogenesis [49].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Pax7
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.74 Pain Relevance 0
The present study demonstrates that in the muscle of the C26 hosts Pax7 expression is significantly increased with respect to controls, while myogenin levels are reduced.
Positive_regulation (increased) of Gene_expression (expression) of Pax7 in muscle
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.70 Pain Relevance 0
During differentiation, phosphorylated ERK, occurring at high levels over days 1–3, progressively declines concomitantly with Pax7 reduction and myogenin and MyoD increases (Fig.
Positive_regulation (increases) of Gene_expression (reduction) of Pax7
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.27 Pain Relevance 0
In the tibialis anterior of the C26 hosts we indeed detected by immunofluorescence microscopy increased levels of Pax7 and caveolin-1 (Fig. 5A), two markers of undifferentiated cells.
Positive_regulation (increased) of Gene_expression (levels) of Pax7 in tibialis anterior
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.54 Pain Relevance 0
The present study suggests an alternative mechanism based on ERK activation: when the C26 hosts are treated with PD, and ERK is thus inhibited, Pax7 and myogenin expression is restored to control values.
Positive_regulation (restored) of Gene_expression (expression) of Pax7
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.40 Pain Relevance 0
At present, the most consistent and reliable marker for satellite cells is the paired-box transcription factor Pax7 and formation of satellite cells occurs via the expression of Pax7 and MyoD and/or Myf5 [30], [31], [32].
Positive_regulation (occurs) of Gene_expression (expression) of Pax7 in satellite cells
7) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.14 Pain Relevance 0

General Comments

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