INT226878

Context Info Confidence 0.33 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.27 Pain Relevance 0.09

cytoskeleton (Mast2) kinase activity (Mast2) cytoplasm (Mast2)

Mast2 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate receptor 2 96.52 Inflammation 44 41.04 cytokine 22 40.00 interstitial cystitis 6 5.00 Inflammatory response 4 5.00 Inflammatory stimuli 4 5.00 imagery 4 5.00 sodium channel 2 5.00 chemokine 2 5.00 Eae 2 5.00

Disease Link Frequency Relevance Heat Cancer 52 76.48 INFLAMMATION 52 41.04 Immune System Diseases 2 40.00 Overactive Bladder 36 33.32 Dermatological Disease 2 6.40 Bladder Cancer 18 5.00 Death 10 5.00 Mycobacterial Infection 8 5.00 Apoptosis 8 5.00 Interstitial Cystitis 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, which is responsible for regulating tryptophan metabolism, FCER2 (Fc fragment of IgE receptor), MAST2 (member of IL-4 signalling, a microtubule associated serine/threonine kinase), GRIA4 (glutamate receptor), and LTA (member of TNF super family).

Gene_expression (fragment) of MAST2 associated with glutamate receptor

1) Confidence 0.33 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.13 Pain Relevance 0.05

Genes correlated with NF-kappaB include INDO (a indoleamine-pyrrole 2,3 dioxygenase that represents a target for IFN-?)

Gene_expression (include) of MAST2

2) Confidence 0.33 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.14 Pain Relevance 0.05

General Comments

This test has worked.