INT226989

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lias) intracellular (Lep) lipid metabolic process (Lep)
extracellular space (Lep) extracellular region (Lep) molecular_function (Lias)
Anatomy Link Frequency
endothelial cells 2
Lias (Rattus norvegicus)
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 6 77.04 Quite High
Hippocampus 10 74.80 Quite High
cerebral cortex 4 74.64 Quite High
Inflammation 10 52.96 Quite High
cytokine 8 22.16 Low Low
Intracerebroventricular 16 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 40 99.56 Very High Very High Very High
Obesity 30 80.76 Quite High
INFLAMMATION 12 52.96 Quite High
Injury 2 34.68 Quite Low
Wound Healing 8 5.00 Very Low Very Low Very Low
Weight Loss 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Ulcers 2 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because LS caused marked increase in leptin production in bovine endothelial cells and because leptin is involved in regulation of body weight we hypothesized that LS might also regulate leptin expression in the brain.
LS Spec (might) Regulation (regulate) of Gene_expression (expression) of leptin in endothelial cells associated with body weight
1) Confidence 0.10 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.61 Pain Relevance 0.11
Such results indicate that the effect of LS on leptin expression is specific.


LS Regulation (effect) of Gene_expression (expression) of leptin
2) Confidence 0.05 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.30 Pain Relevance 0.19

General Comments

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