INT22720

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Context Info
Confidence 0.24
First Reported 1980
Last Reported 1990
Negated 3
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.34
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
hippocampus 2
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 4 98.86 Very High Very High Very High
noradrenaline 9 98.64 Very High Very High Very High
Hippocampus 3 98.08 Very High Very High Very High
tetrodotoxin 2 92.96 High High
Intracerebroventricular 1 64.84 Quite High
Disease Link Frequency Relevance Heat
Aggression 1 91.68 High High
Paralysis 1 86.76 High High
Sleep Disorders 1 86.72 High High
Muscular Atrophy 1 78.08 Quite High
Dementia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of oxotremorine and the cyclic GMP derivatives were not due to diminished ACh synthesis, since these compounds did not influence the reduction of tissue ACh resulting from treatment with K+ and atropine.
Neg (not) Regulation (influence) of Negative_regulation (reduction) of ACh
1) Confidence 0.24 Published 1980 Journal Brain Res. Section Abstract Doc Link 6243230 Disease Relevance 0 Pain Relevance 0.09
In contrast, the total number of AChRs per endplate was unaffected by these treatments.
Neg (unaffected) Regulation (unaffected) of Negative_regulation (number) of AChRs
2) Confidence 0.23 Published 1990 Journal Neuron Section Abstract Doc Link 2322461 Disease Relevance 0.16 Pain Relevance 0.09
Chronic treatment of AF64A-injected rats with clonidine (0.02-0.2 mg/kg, i.p., every 8-12 h) had no significant effect on the loss of ACh content, whereas the decrease in NA content in hippocampus was completely prevented.
Neg (no) Regulation (effect) of Negative_regulation (loss) of ACh in hippocampus associated with noradrenaline, hippocampus and clonidine
3) Confidence 0.14 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2918312 Disease Relevance 0.18 Pain Relevance 0.86

General Comments

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